Lancet Gastroen Hepatol:男男性行为人群的HCV风险研究

2020-11-18 MedSci原创 MedSci原创

HIV阳性的男男性行为人群的HCV感染风险大大增加,而艾滋病暴露前预防使用频率的增加,相应的HCV感染风险也显著增加

男男性行为人群(MSM)是丙型肝炎病毒(HCV)传播的高危人群,近日研究人员开展系统综述及荟萃分析,就MSM人群的HCV的流行率和发病率进行了考察。
 
研究人员对2000年1月1日至2019年10月31日期间发表在MEDLINE或Embase上的研究进行了系统回顾和荟萃分析,包括会议记录。符合要求的研究报告了MSM中HCV流行率或HCV发病率(或两者兼而有之)。
 
194个研究纳入本次系统综述及荟萃分析。总体上,MSM人群的合并HCV患病率为3.4%,其中非洲(5.8%)和东南亚(5.0%)地区最高。在全球范围内,HIV阴性MSM人群的HCV患病率为1.5%,HIV阳性人群为6.3%。与一般人群相比,HIV阴性MSM人群HCV患病率略高,HIV阳性MSM人群明显升高。在曾经注射过药物(30.2%)或目前正在注射药物(45.6%)的MSM人群中, HCV患病率显著高于从未注射过药物的人群 (2.7%)。在HIV阴性的MSM中,非艾滋病暴露前预防(PrEP)个体的合并HCV发病率为0.12/1000人-年,PrEP个体为14.80/1000人-年。在HIV-阳性的MSM中,HCV发病率为8.46/1000人-年。
 
研究发现,HIV阳性的男男性行为人群的HCV感染风险大大增加,而艾滋病暴露前预防使用频率的增加,相应的HCV感染风险也显著增加。
 
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    2021-05-19 许安
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encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Dec 19 15:22:13 CST 2020, time=2020-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257787, encodeId=0ba2125e78702, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322385, encodeId=edcb1322385e1, content=<a href='/topic/show?id=cde152e227a' target=_blank style='color:#2F92EE;'>#性行为#</a>, beContent=null, objectType=article, channel=null, level=null, 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target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034051, encodeId=eaf810340512e, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Nov 18 22:22:13 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2020-12-19 howi
  5. 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likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52722, encryptionId=cde152e227a, topicName=性行为)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378905, encodeId=bb3613e89054d, content=<a href='/topic/show?id=7dafe027380' target=_blank style='color:#2F92EE;'>#男男性行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70273, encryptionId=7dafe027380, topicName=男男性行为)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427471, encodeId=0ae7142e471b0, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034051, encodeId=eaf810340512e, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Nov 18 22:22:13 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2020-11-20 ymljack
  6. 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target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034051, encodeId=eaf810340512e, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Nov 18 22:22:13 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2020-11-20 xugc
  7. 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target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), 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  8. 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target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034051, encodeId=eaf810340512e, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Nov 18 22:22:13 CST 2020, time=2020-11-18, status=1, ipAttribution=)]
    2020-11-20 gwc384
  9. 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target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), 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    2020-11-19 Jessica

    HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加

    0

  10. 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target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Fri Nov 20 10:22:13 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900401, encodeId=f84390040123, content=HIV阳性的男男性行为人群的丙型肝炎病毒感染风险大大增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Nov 19 10:11:40 CST 2020, time=2020-11-19, status=1, ipAttribution=), 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    2020-11-18 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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