AP&T:慢性乙型肝炎患者队列中的疾病合并症随时间增加

2020-07-06 MedSci原创 MedSci原创

慢性乙型肝炎(CHB)患者是否比非CHB患者有更多的非肝脏合并症存在争议。为了表征韩国CHB患者的人口统计学,合并症和健康利用情况,本项研究对合格患者进行了相关研究。

背景

慢性乙型肝炎(CHB)患者是否比非CHB患者有更多的非肝脏合并症存在争议。为了表征韩国CHB患者的人口统计学,合并症和健康利用情况,本项研究对合格患者进行了相关研究。

 

方法

研究人员使用韩国健康保险审查与评估服务(HIRA)2007-2016数据库,对患有CHB的成年患者进行分析。CHB病例和非CHB对照者使用倾向得分匹配方法以1:4的比例匹配。

 

结果

CHB患者的年龄从2007年的平均46.9岁显着增加到2016年的52.3岁。与相匹配的对照组相比,CHB患者中有肝相关和非肝相关合并症的人的比例更高(血脂异常[37.23%vs 23.77%,P<0.0001],高血压[29.39%vs 25.27%,P<0.0001],慢性肾脏病(CKD)[3.02%vs 1.14%,P<0.0001]和骨质疏松/骨折[OF] [4.09%vs 3.23% ,P<0.0001])。大约50%的CHB患者在CKD,糖尿病,DLP和OF中合并症多于一种。调整混杂因素后,CHB患者中CKD的机率比匹配对照组高1.42倍,CHB患者中骨折的机率比对照高1.09倍(P <0.0001)。

 

结论

CHB患者的肝脏以及非肝合并症的患病率高于对照组,并且随时间增加。

原始出处:

Hyunwoo Oh. et al. Increasing comorbidities in a South Korea insured population‐based cohort of patients with chronic hepatitis B. Alimentary Pharmacology and Therapeutics.2020.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1825727, encodeId=bba41825e27ef, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Sat Apr 10 23:36:27 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825886, encodeId=1fc0182588684, content=<a href='/topic/show?id=c52d388137b' target=_blank style='color:#2F92EE;'>#合并症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38813, encryptionId=c52d388137b, topicName=合并症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Aug 29 22:36:27 CST 2020, time=2020-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807897, encodeId=7dea180e897fc, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sun Aug 09 08:36:27 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271303, encodeId=f1af12e1303df, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jul 08 01:36:27 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1825727, encodeId=bba41825e27ef, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Sat Apr 10 23:36:27 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825886, encodeId=1fc0182588684, content=<a href='/topic/show?id=c52d388137b' target=_blank style='color:#2F92EE;'>#合并症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38813, encryptionId=c52d388137b, topicName=合并症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Aug 29 22:36:27 CST 2020, time=2020-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807897, encodeId=7dea180e897fc, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sun Aug 09 08:36:27 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271303, encodeId=f1af12e1303df, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jul 08 01:36:27 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1825727, encodeId=bba41825e27ef, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Sat Apr 10 23:36:27 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825886, encodeId=1fc0182588684, content=<a href='/topic/show?id=c52d388137b' target=_blank style='color:#2F92EE;'>#合并症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38813, encryptionId=c52d388137b, topicName=合并症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Aug 29 22:36:27 CST 2020, time=2020-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807897, encodeId=7dea180e897fc, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sun Aug 09 08:36:27 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271303, encodeId=f1af12e1303df, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jul 08 01:36:27 CST 2020, time=2020-07-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1825727, encodeId=bba41825e27ef, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Sat Apr 10 23:36:27 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825886, encodeId=1fc0182588684, content=<a href='/topic/show?id=c52d388137b' target=_blank style='color:#2F92EE;'>#合并症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38813, encryptionId=c52d388137b, topicName=合并症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Aug 29 22:36:27 CST 2020, time=2020-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807897, encodeId=7dea180e897fc, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sun Aug 09 08:36:27 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271303, encodeId=f1af12e1303df, content=<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53463, encryptionId=3d745346316, topicName=慢性乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jul 08 01:36:27 CST 2020, time=2020-07-08, status=1, ipAttribution=)]

相关资讯

它是乙型肝炎的“始作俑者”

慢性乙型肝炎病毒(HBV)感染在全球范围内是导致肝脏疾病的常见原因。据WHO统计,全球有约2.57亿HBV感染患者。HBV-DNA是病毒的核心部分,病毒的基因都在这里,没有核酸,病毒就不能复制。

J Gastroenterology: 血清乙肝核心相关抗原可预测乙肝e抗原阴性患者的肝细胞癌的发生

乙肝核心相关抗原(HBcrAg)是一种新型的血清病毒标志物。最近的研究表明,其水平与慢性乙型肝炎(CHB)患者的肝细胞癌(HCC)风险相关。本项研究旨在评估基线时血清HBsAg和HBcrAg水平预测

AJG:乙型肝炎核心抗体阳性与非酒精性脂肪肝疾病中的肝硬化和肝细胞癌相关

有研究报道,先前接触过乙型肝炎病毒(HBV)可能会增加慢性丙型肝炎患者患肝细胞癌(HCC)的风险。本项研究旨在研究先前HBV感染对非酒精性脂肪肝疾病(NAFLD)患者的严重程度和预后的影响。

Hepatol Int:乙型肝炎治疗患者肝癌发生风险:替诺福韦低于恩替卡韦

富马酸替诺福韦(TDF)在降低乙型肝炎患者肝细胞癌发生风险上是否优于恩替卡韦(ETV)目前仍存在争议。本研究拟从临床医学和方法学两方面的角度,通过荟萃分析来探讨这一问题。

乙肝“大三阳”三个月转阴?--这几点干货你必须了解一下

众所周知,曾经我国的乙肝感染率非常高,但自从2005年3月24日,我国颁布了第434号国务院令并公布了《疫苗流通和预防接种管内理条例》,要求对全国所有新生儿实行乙肝疫苗的免费接种,我国的乙肝感染率在逐

Cell Death Dis:线粒体泛素连接酶MARCH5或可作为乙肝诱导性肝病的治疗靶点

乙型肝炎病毒(HBV)感染会增加慢性肝病和肝细胞癌(HCC)的发生率。 HBV基因组编码的乙型肝炎病毒x蛋白(HBx)对于HCC的发病具有重要贡献,因此,负性调控HBx或有利于缓解疾病的发病进程。 MARCH5是线粒体E3泛素连接酶,该研究发现高MARCH5表达与HCC患者的高存活率相关。MARCH5能够与主要积累于在线粒体中的HBx蛋白相互作用并将其靶向降解。MARCH5的N端RING结构域对于