Lancet:非洲新冠肺炎重症患者死亡率近50%

2021-05-22 MedSci原创 MedSci原创

与其他地区相比,非洲新冠肺炎重症患者的死亡率较高,重症医疗资源匮乏、HIV、糖尿病、慢性肝肾疾病以及入院时器官功能障碍的严重程度均与非洲新冠肺炎重症患者死亡率较高相关。

全球新冠肺炎疫情仍在持续,全球范围内Covid-19病例的死亡率约为3%,而在医疗资源匮乏地区,新冠肺炎造成的影响将难以估量。近日研究人员开展非洲Covid-19危重患者护理结果研究(ACCCOS)旨在确定与非洲新冠肺炎危重患者死亡率相关的医疗资源、共症和危重症护理干预因素

ACCCOS研究是一项多中心、前瞻性、观察性队列研究,成年的疑似或确诊新冠肺炎患者参与,患者被移送至10个国家的64个重症监护病房或高症监护病房进行治疗。研究的主要终点是30天院内死亡。

2020年5月至12月期间,6779名患者参与ACCCOS研究,平均年龄55.6岁,男性占60.6%,平均每个医院中有2名重症医学医生,86%的患者可以接受血氧含量测量。入院30天内,患者院内死亡率高达48.2%。与死亡风险增加相关的独立因素包括高龄(年龄每增加1岁,死亡风险比为1.03)、HIV/AIDS(1.91)、糖尿病(1.25)、慢性肝病(3.48)、慢性肾病(1.89)、因医疗资源匮乏导致的延迟治疗(2.14)、入院器官衰竭评估评分(1-3个相关因素导致的风险比分别为1.44、2.0以及3.66)、呼吸支持(接受高流量氧、持续正压通气以及机械通气患者的死亡风险比分别为2.72、3.93以及15.27)、入院后24小时内心肺骤停(4.43)以及升压素治疗(3.67)。激素治疗可改善患者生存(死亡风险比0.55),女性患者的预后差异不明显(0.86)。

年龄、体重、性别以及共病因素对新冠肺炎死亡率的影响

研究认为,与其他地区相比,非洲新冠肺炎重症患者的死亡率较高,重症医疗资源匮乏、HIV、糖尿病、慢性肝肾疾病以及入院时器官功能障碍的严重程度均与非洲新冠肺炎重症患者死亡率较高相关

原始出处:

The African COVID-19 Critical Care Outcomes Study (ACCCOS) Investigators. Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study.Lancet. May 22, 2021.

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    2021-07-25 howi
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    2021-05-22 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2021-05-22 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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