Nat Metab:母亲运动通过改变母乳成分,促进后代代谢健康

2020-07-06 MedSci原创 MedSci原创

研究人员确定了运动可以诱导人和小鼠母乳中低聚糖3′-唾液乳糖(3′-SL)的增加,并表明母体运动对小鼠后代代谢健康和心脏功能的有益影响是由3′-SL介导的。

已有的研究显示,营养不足或营养过剩等不良孕产环境可增加后代患肥胖症、2型糖尿病血管疾病的风险。

最近在动物模型中的研究表明,孕产妇在怀孕前和怀孕期间的运动可以减轻后代随着年龄增长出现的糖代谢受损,心血管功能下降和脂肪增加的风险。

然而,至今为止,关于孕产妇运动改善后代健康的基本机制尚未确定。

在最近的这项研究中,研究人员确定了运动可以诱导人和小鼠母乳中低聚糖3′-唾液乳糖(3′-SL)的增加,并表明母体运动对小鼠后代代谢健康和心脏功能的有益影响是由3′-SL介导的。

在全身3′-SL基因敲除的小鼠(3′-SL-/-)中,母体运动训练未能改善小鼠后代代谢健康或心脏功能。食用运动训练过的3′-SL敲除的母鼠奶水的野生型后代没有任何益处,而在哺乳期给野生型小鼠补充3′-SL则能改善后代成年后的代谢健康和心脏功能。

重要的是,补充3′-SL可以消除高脂饮食对身体成分和代谢的不利影响。

因此,本研究揭示了母乳中的低聚糖3′-SL在调解母体运动对后代健康影响方面的关键作用。补充3′-SL是一种潜在的治疗方法,可以防治肥胖症、2型糖尿病和心血管疾病的发生。

 

原始出处:

Johan E. Harris et al. Exercise-induced 3′-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring. Nature Metabolism (2020). 

 

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    2020-11-29 一闲
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    2020-09-10 liye789132251
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    2020-10-29 guojianrong
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    2020-07-08 villahu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1896692, encodeId=2fad18966926e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Nov 29 23:36:49 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884439, encodeId=dc761884439fa, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Sep 10 13:36:49 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888166, encodeId=d72618881662a, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Oct 29 15:36:49 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299628, encodeId=9b441299628ae, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Wed Jul 08 02:36:49 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571400, encodeId=a24715e14002a, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Wed Jul 08 02:36:49 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801570, encodeId=551c8015e04b, content=学习了,哺乳期也要注意锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Tue Jul 07 07:26:01 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801453, encodeId=e83d8014539e, content=父母对后代的影响,这里研究一直都比较火热,建议大家多关注。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 06 14:22:06 CST 2020, time=2020-07-06, status=1, ipAttribution=)]
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    2020-07-07 1240394fm61暂无昵称

    学习了,哺乳期也要注意锻炼

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1896692, encodeId=2fad18966926e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Nov 29 23:36:49 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884439, encodeId=dc761884439fa, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Sep 10 13:36:49 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888166, encodeId=d72618881662a, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Oct 29 15:36:49 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299628, encodeId=9b441299628ae, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Wed Jul 08 02:36:49 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571400, encodeId=a24715e14002a, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Wed Jul 08 02:36:49 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801570, encodeId=551c8015e04b, content=学习了,哺乳期也要注意锻炼, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Tue Jul 07 07:26:01 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801453, encodeId=e83d8014539e, content=父母对后代的影响,这里研究一直都比较火热,建议大家多关注。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 06 14:22:06 CST 2020, time=2020-07-06, status=1, ipAttribution=)]
    2020-07-06 lovetcm

    父母对后代的影响,这里研究一直都比较火热,建议大家多关注。

    1

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