Clin Gastroenterology H:年纪越大,炎症性肠病患者患有慢性肾脏病的风险越低

2020-08-30 MedSci原创 MedSci原创

目前尚不清楚哪些因素会影响炎症性肠病(IBD)患者患有慢性肾脏病(CKD)风险

背景与目标

目前尚不清楚哪些因素会影响炎症性肠病(IBD)患者患有慢性肾脏病(CKD)风险;有相当一部分研究认为5-氨基水杨酸酯(5-ASAs)会增加了患CKD的风险, 但是也有研究持相反意见。本项研究旨在探究IBD患者中CKD的相对危险度,并针对CKD危险因素进行调整,并确定治疗IBD药物是否与肾小球滤过率(eGFR)改变相关。

 

方法

本项研究为一项回顾性研究。17807名IBD患者的年龄,性别和行为与63466名非IBD患者相匹配。使用针对普通CKD危险因素调整的Cox比例危险模型,并计算IBD患者CKD在第3至5D期的相对危险度。同时研究人员还使用纵向模型评估了5-ASAs,硫唑嘌呤和甲氨蝶呤与eGFR变化的关系。

 

结果

在控制了与CKD相关的危险因素后,研究人员发现IBD与16-77岁患者的CKD发生有关。随着患者年龄的增加,调整后的CKD危险比从16岁时的7.88(95%CI,2.56–24.19)降低至77岁时的1.13(95%CI,1.01–1.25)。在纵向分析中,接触5-ASAs或甲氨蝶呤与eGFR的变化无关,而硫唑嘌呤与eGFR稍高的相关(P=0.001)。

(年纪越大CKD风险越小)

 

结论

在这项对超过80000人的回顾性研究中,研究人员发现IBD与CKD风险增加相关,且年轻患者中的危险比最高。常用的非生物治疗剂与较低的eGFR无关。

 

 

原始出处:

Ravy K. Vajravelu. Et al. Inflammatory Bowel Diseases Are Associated With an Increased Risk for Chronic Kidney Disease, Which Decreases With Age. Clin Gastroenterology H.2020.

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    2021-03-31 许安
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2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881007, encodeId=806c88100eab, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3c5410793, createdName=蓝莓, createdTime=Sun Aug 30 18:39:41 CST 2020, time=2020-08-30, status=1, ipAttribution=)]
    2020-09-23 风间皎月

    很多慢性病都是越年轻预后越不好。

    0

  5. 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2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881007, encodeId=806c88100eab, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3c5410793, createdName=蓝莓, createdTime=Sun Aug 30 18:39:41 CST 2020, time=2020-08-30, status=1, ipAttribution=)]
    2020-09-03 阿勇233

    学习一

    0

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    2020-08-30 蓝莓

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