J Clin Rheumatol:脉络膜厚度可以反应强直性脊柱炎的治疗效果

2021-05-04 MedSci原创 MedSci原创

脉络膜厚度(CT)已被评估为强直性脊柱炎(AS)系统性炎症的一个标志。近日,一项纵向的多中心研究评估了AS患者在接受生物治疗前后6个月的CT,研究结果已发表于J Clin Rheumatol。

脉络膜厚度(CT)已被评估为强直性脊柱炎(AS)系统性炎症的一个标志。近日,一项纵向的多中心研究评估了AS患者在接受生物治疗前后6个月的CT,研究结果已发表于J Clin Rheumatol。

研究纳入了44名AS患者,年龄为18-65岁,计算了CT和C反应蛋白(CRP)与疾病活动指数之间的相关性。测定了CT和CRP之间的吻合度。评估了与治疗反应相关的因素。临床上重要的改善被定义为强直性脊柱炎疾病活动评分减少1.1分或更多。

 

结果显示,基线的平均CT值明显高于治疗6个月后(基线:355.28±80.46μm;6个月:341.26±81.06μm;P<0.001)。基线和6个月时,CT和CRP之间有95%的一致性。临床上重要的改善与较低的基线CT(OR,0.97[95%置信区间,0.91-0.93;P = 0.009]和年龄0.81[95%置信区间,0.7-0.95;P = 0.005])独立相关,基线CT小于374μm(敏感性78%,特异性78%,曲线下面积0.70,似然比3.6)。

 

总之,该研究结果显示,所有治疗组的脉络膜厚度在6个月的生物治疗后明显下降。脉络膜厚度和CRP的一致性为95%。高CT与生物治疗失败的风险有关。脉络膜厚度可以被认为是炎症的一个有用的生物标志物,也是与AS的治疗反应有关的因素。

 

原始出处:

 

Martina Steiner, et al., Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis. J Clin Rheumatol. 2020 Jul 1. doi: 10.1097/RHU.0000000000001458. Online ahead of print.

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    2021-09-05 zywlvao
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    2022-01-05 屋顶瞄爱赏月

    学习了

    0

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    2021-05-04 小小医者

    #强直性脊柱炎#与眼部联系起来了!高手!

    0

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    2021-05-04 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2021-05-04 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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