JACC:联合临床和基因风险评估可更好地预防冠心病

2020-06-09 MedSci原创 MedSci原创

冠心病(CAD)的多基因危险度评分(PRS)确定高危人群更有可能从一级预防他汀类药物治疗中获益。本研究的目的旨在将多基因风险评估与基于指南的冠心病一级预防建议和管理模式相结合。

冠心病(CAD)的多基因危险度评分(PRS)确定高危人群更有可能从一级预防他汀类药物治疗中获益。本研究的目的旨在将多基因风险评估与基于指南的冠心病一级预防建议和管理模式相结合。

本研究纳入分析了47108名参与者(平均年龄60岁),其中有11020名(23.4%)患有冠心病。冠心病PRS与冠心病的发生呈强相关(p < 0.0001),多基因高风险(前20%的PRS)使CAD发生的几率增加了1.9倍(p<0.0001)。然而,在一级预防患者(n=33251)中,高多基因风险与美国心脏病学会/美国心脏病协会(46.2%的高PRS患者与46.8%的其他患者相比,p=0.54)或美国预防服务特别工作组(43.7%对43.7%,p=0.99)对他汀类药物治疗的更高建议不一致。如果将冠心病PRS作为指南推荐因素的话,会多出4.1%的一级预防的患者接受他汀类药物治疗。

研究结果显示,目前血管疾病一级预防的模式未能完全捕获冠心病的多基因易感性,通过整合遗传和临床风险,可能有机会改进冠心病预防工作。

原始出处:

Krishna G et al.Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.JACC.2020 June.

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