Nat Commun:先天性巨细胞病毒感染婴幼儿的血液基因组表达分析

2020-08-05 AlexYang MedSci原创

先天性CMV感染(cCMVi)影响这全世界0.5%-1%的新生儿,也是导致感音神经性听力损失(SNHL)的主要原因。大多数cCMVi婴幼儿在出生时听力正常,但是处在晚发SNHL的风险中。

先天性CMV感染(cCMVi)影响这全世界0.5%-1%的新生儿,也是导致感音神经性听力损失(SNHL)的主要原因。大多数cCMVi婴幼儿在出生时听力正常,但是处在晚发SNHL的风险中。

目前,在这些婴幼儿中预测SNHL发展的可靠的生物标记仍旧缺乏。最近,有研究人员在80名cCMVi婴幼儿中进行了血液转录分析( 其中49名有症状,31名无症状),这些婴幼儿均不大于3周。之后,研究人员对这些婴幼儿进行了跟踪调查来评估晚发SNHL情况。研究发现,有症状和无症状cCMVi的生物特征无法区分,表明了有症状和无症状cCMVi婴幼儿的免疫响应没有差别。

cCMV感染婴幼儿晚发SNHL分类基因

对cCMVi婴儿的初始样本进行 Random forest 分析发现,无论其临床分类如何,都能以92%的准确率识别出与SNHL发展相关的16个基因分类特征,表明了其作为生物标志物的潜在价值。

原始出处:

Christopher P Ouellette , Pablo J Sánchez , Zhaohui Xu et al. Blood genome expression profiles in infants with congenital cytomegalovirus infection. Nat Commun. July 2020

 

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    2020-11-17 liuli5079
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Aug 05 18:05:07 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806330, encodeId=b25280633029, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Wed Aug 05 15:18:21 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2021-03-06 liye789132251
  5. [GetPortalCommentsPageByObjectIdResponse(id=1936636, encodeId=b6251936636b3, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Sat Jul 10 23:16:29 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928341, encodeId=fe701928341a1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, 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    2020-08-07 huirong
  6. [GetPortalCommentsPageByObjectIdResponse(id=1936636, encodeId=b6251936636b3, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Sat Jul 10 23:16:29 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928341, encodeId=fe701928341a1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, 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    2020-08-07 wwzzly
  7. 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    2020-08-06 ms3000000449926787

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    2020-08-05 ms3000000449926787

    学习

    0

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