JAAPOS:右美托咪定静脉用药增强眼心反射

2018-08-12 田磊 罂粟花

我们先前已经报道经鼻右美托咪定预用药与更强烈的眼心反射(OCR)有关。在本研究中,我们进行了一次体内静脉用药比较,以验证我们的假设,即这种α2肾上腺素能激动剂能增强三叉-迷走神经反射。

背景与目的:我们先前已经报道经鼻右美托咪定预用药与更强烈的眼心反射(OCR)有关。在本研究中,我们进行了一次体内静脉用药比较,以验证我们的假设,即这种α2肾上腺素能激动剂能增强三叉-迷走神经反射。

方法:在斜视手术中,采用10秒,200 g张力方波对下直肌或其他肌肉进行OCR(最大改变心率/基线心率)前瞻性监测。在第一和第二肌肉OCR之间,右美托咪定0.5μg/kg静脉泵注。

结果:所有患者均无应用抗胆碱能药物。共842名历史对照病人(中位年龄,5.5岁)在行肌肉第一次OCR(75%±24%)和第二次OCR(77%±22%)间没有静脉给与右美托咪定。33名研究对象(中位年龄,5.6岁)行肌肉第一次OCR(84%±16%),静脉给与右美托咪定行第二次OCR(66%±25%),心动过缓增加18%±19%(P<0.01)。

结论:与芬太尼的作用相似,静脉快速推右美托咪定可增强眼外肌牵引引起的心动过缓。

原始出处

Arnold RW, et al. Intravenous dexmedetomidine augments the oculocardiac reflex. Journal of AAPOS, 2018, 22(3):211-213.

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    2018-10-16 fusion
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    2019-05-10 ylz8410
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    2018-08-12 天地飞扬

    了解一下,谢谢分享!

    0