Phytother Res:补充白藜芦醇对2型糖尿病患者心脏代谢危险因素的影响

2020-07-06 MedSci原创 MedSci原创

本研究旨在评估微粉化白藜芦醇补充剂对2型糖尿病(T2DM)患者血糖状态,脂质分布和身体成分的影响。

本研究旨在评估微粉化白藜芦醇补充剂对2型糖尿病(T2DM)患者血糖状态,脂质分布和身体成分的影响。

 

研究人员随机分配了71名超重的T2DM患者(体重指数范围为25-30),接受1000 mg /天的反式白藜芦醇或安慰剂(甲基纤维素)治疗8周。干预前后测量人体测量指标和生化指标,包括脂质和血糖分布。

 

结果显示,在校正后的模型(年龄,性别和基线体重指数)中,与安慰剂相比,白藜芦醇降低了空腹血糖(-7.97±13.6 mg / dL,p = 0.05),并增加了高密度脂蛋白(3.62±8.75 mg / dL,p = 0.01)水平。此外,胰岛素水平的平均差异有显著性(-0.97±1.91,μIU/ mL,p = 0.02)。但是,人体测量方法没有观察到明显差异。

 

综上所述,该研究表面,补充白藜芦醇8周可改善T2DM患者的某些心脏代谢参数,但是仍需要更多的研究来证实这些发现。

 

原始出处:

 

Shima Abdollahi, Amin Salehi-Abargouei, et al., The Effect of Resveratrol Supplementation on Cardio-Metabolic Risk Factors in Patients With Type 2 Diabetes: A Randomized, Double-Blind Controlled Trial. Phytother Res. 2019 Dec;33(12):3153-3162. doi: 10.1002/ptr.6487.  

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