JAMA Oncology:抗生素降低了采用免疫疗法的癌症患者的存活率

2019-09-15 Allan MedSci原创

如果癌症患者近期服用抗生素,他们对免疫疗法的反应率和整体存活率会更差。该研究结果来自英国近200名癌症患者的一项研究,患者采用了检查点抑制剂疗法。

如果癌症患者近期服用抗生素,他们对免疫疗法的反应率和整体存活率会更差。该研究结果来自英国近200名癌症患者的一项研究,患者采用了检查点抑制剂疗法。这项前瞻性研究由伦敦帝国理工学院的研究人员领导,近日发表在JAMA Oncology期刊上,强调了抗生素治疗时机的重要性以及进一步研究其作用机制的必要性。

研究人员发现,在开始治疗前一个月接受广谱抗生素治疗的患者对免疫治疗的反应明显较差,免疫治疗前的抗生素治疗与较低的总生存率相关,癌症更有可能进展。与免疫治疗一起接受抗生素或根本不接受抗生素治疗的患者的治疗结果较好。研究人员认为这可能是因为抗生素会破坏肠道内细菌和微生物的平衡,进而影响免疫系统。


原始出处:

http://www.firstwordpharma.com/node/1666351#axzz5zb5vvosj

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    2019-12-11 daviiliu
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    2020-04-12 minlingfeng
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createdBy=068d2446376, createdName=Dr Z, createdTime=Mon Sep 16 07:30:27 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372784, encodeId=367e3e278404, content=研究证据级别高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/20/dafb36f63f4241903de36c3d053babb8.jpg, createdBy=d367105945, createdName=Midas, createdTime=Mon Sep 16 07:11:52 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372779, encodeId=04513e2779ec, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Sep 16 06:13:15 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-19 12546fb1m09暂无昵称

    观点好新

    0

  5. 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  6. 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createdBy=068d2446376, createdName=Dr Z, createdTime=Mon Sep 16 07:30:27 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372784, encodeId=367e3e278404, content=研究证据级别高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/20/dafb36f63f4241903de36c3d053babb8.jpg, createdBy=d367105945, createdName=Midas, createdTime=Mon Sep 16 07:11:52 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372779, encodeId=04513e2779ec, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Sep 16 06:13:15 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-17 lovetcm

    肠道菌群有关,也许应该研究补充益生菌与肿瘤免疫治疗的关系了

    0

  7. 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createdBy=068d2446376, createdName=Dr Z, createdTime=Mon Sep 16 07:30:27 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372784, encodeId=367e3e278404, content=研究证据级别高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/20/dafb36f63f4241903de36c3d053babb8.jpg, createdBy=d367105945, createdName=Midas, createdTime=Mon Sep 16 07:11:52 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372779, encodeId=04513e2779ec, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Sep 16 06:13:15 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 一天没事干

    很好的学习机会

    0

  8. 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createdName=12546fb1m09暂无昵称, createdTime=Thu Sep 19 01:24:07 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289648, encodeId=ea291289648d9, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Tue Sep 17 13:27:00 CST 2019, time=2019-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372824, encodeId=72f83e282414, content=肠道菌群有关,也许应该研究补充益生菌与肿瘤免疫治疗的关系了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Sep 17 05:36:58 CST 2019, time=2019-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372788, encodeId=c7db3e27883e, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Mon Sep 16 08:23:26 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372787, encodeId=f4513e2787b6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Mon Sep 16 07:30:27 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372784, encodeId=367e3e278404, content=研究证据级别高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/20/dafb36f63f4241903de36c3d053babb8.jpg, createdBy=d367105945, createdName=Midas, createdTime=Mon Sep 16 07:11:52 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372779, encodeId=04513e2779ec, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Sep 16 06:13:15 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 Dr Z

    学习了

    0

  9. 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createdName=12546fb1m09暂无昵称, createdTime=Thu Sep 19 01:24:07 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289648, encodeId=ea291289648d9, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Tue Sep 17 13:27:00 CST 2019, time=2019-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372824, encodeId=72f83e282414, content=肠道菌群有关,也许应该研究补充益生菌与肿瘤免疫治疗的关系了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Tue Sep 17 05:36:58 CST 2019, time=2019-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372788, encodeId=c7db3e27883e, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Mon Sep 16 08:23:26 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372787, encodeId=f4513e2787b6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/08/03/0e492dda8bcc1f98474b74c2863aca87.jpg, createdBy=068d2446376, createdName=Dr Z, createdTime=Mon Sep 16 07:30:27 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372784, encodeId=367e3e278404, content=研究证据级别高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/20/dafb36f63f4241903de36c3d053babb8.jpg, createdBy=d367105945, createdName=Midas, createdTime=Mon Sep 16 07:11:52 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372779, encodeId=04513e2779ec, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Sep 16 06:13:15 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 Midas

    研究证据级别高吗?

    0

  10. 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createdBy=068d2446376, createdName=Dr Z, createdTime=Mon Sep 16 07:30:27 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372784, encodeId=367e3e278404, content=研究证据级别高吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/12/20/dafb36f63f4241903de36c3d053babb8.jpg, createdBy=d367105945, createdName=Midas, createdTime=Mon Sep 16 07:11:52 CST 2019, time=2019-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372779, encodeId=04513e2779ec, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Sep 16 06:13:15 CST 2019, time=2019-09-16, status=1, ipAttribution=)]
    2019-09-16 yjs木玉

    好好好好好好

    0

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