JAHA:加利福尼亚州妊娠相关心肌梗死的发病率和机制变化

2021-10-22 MedSci原创 MedSci原创

在过去的十年中,加利福尼亚州的PAMI发病率呈上升趋势,自发性冠状动脉夹层、血管痉挛和Takotsubo综合征的发病机制呈上升趋势。这些结果值得进一步调查。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在评估加利福尼亚州妊娠相关心肌梗死(PAMI)的时间趋势,并探索潜在的危险因素和发病机制。

研究人员采用加利福尼亚州住院患者数据库分析了2003年至2011年期间国际疾病分类第九修订版(ICD-9)代码为妊娠或产后急性心肌梗塞入院患者;并对危险因素进行了分析,且与未发生心肌梗死的妊娠患者进行比较。

研究人员总共从5266380次妊娠(每100000次妊娠中发生6.5次)中确定了341名PAMI患者。PAMI患者住院孕产妇死亡率为7%,婴儿死亡率为3.5%。从2003年到2011年,PAMI发病率没有显著增加的趋势,这可能是由于自发性冠状动脉夹层、血管痉挛和Takotsubo综合征的发生率较高。

与未患心肌梗塞的孕妇相比,PAMI对年龄较大(72% vs. 37%,P<0.0005)、黑人(12% vs. 6%,P<0.00005)、年龄大于30岁、较低的社会经济地位(最低四分位数的家庭收入中位数为26% vs. 20%,P=0.04),较高的高血压患病率(26% vs. 7%,P<0.0005),糖尿病(7% vs. 1%,P<0.0005),贫血(31% vs. 7%,P<0.0001)、使用苯丙胺(1% vs. 0%,P<0.00005)、可卡因(2% vs. 0.2%,P<0.0001)和吸烟(6% vs. 1%,P=0.0001)相关。

由此可见,在过去的十年中,加利福尼亚州的PAMI发病率呈上升趋势,自发性冠状动脉夹层、血管痉挛和Takotsubo综合征的发病机制呈上升趋势。这些结果值得进一步调查。

原始出处:

Sawan Jalnapurkar.et al.Changing Incidence and Mechanism of Pregnancy‐Associated Myocardial Infarction in the State of California.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021056

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1823762, encodeId=fda31823e622d, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Dec 23 09:38:28 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068204, encodeId=fa7910682045a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=10b65509612, createdName=小雨闲, createdTime=Mon Nov 08 19:33:20 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268653, encodeId=abf21268653c1, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Oct 24 07:38:28 CST 2021, time=2021-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062983, encodeId=d43f1062983b5, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82782282241, createdName=121ca41bm98暂无昵称, createdTime=Fri Oct 22 16:44:20 CST 2021, time=2021-10-22, status=1, ipAttribution=)]
    2021-11-08 小雨闲

    学习

    0

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    2021-10-24 zhaohui6731
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    2021-10-22 121ca41bm98暂无昵称

    不错不错

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