Sci Rep:高CD3和ICOS及低TIM-3表达预测食管鳞状细胞癌切除后的生存率良好

2020-01-10 xiangting MedSci原创

CD3+ TIL和T细胞ICOS表达升高与良好的预后相关,而高TIM-3表达则提示预后不良。

随着免疫疗法治疗肿瘤的潜力逐渐增加,几种免疫检查点调节剂正在研究中。包括程序性细胞死亡配体-1、程序性细胞死亡-1PD-1)、诱导型共刺激分子(ICOS)、淋巴细胞激活基因-3T细胞免疫球蛋白和粘蛋白结构域分子-3TIM-3)在内免疫标记物的价值并不清楚。

研究使用396例接受食管鳞状细胞癌(ESCC)手术患者的组织芯片,​​对浸润的T细胞亚群(CD3CD8Foxp3)和检查点蛋白表达进行了评分。

中位随访24.8个月,CD3+ TIL亚组(50.0%)的中位无复发生存期(RFS55.0 vs 21.4个月)和总生存期更长(OS77.7 vs 35.8个月)。高ICOS表达的患者(46.5%)中位RFS53.9 vs 25.3个月)和OS更长(88.8 vs 36.9个月)。PD-1高表达组(45.2%)的RFS(危险比[HR] 0.67)和OSHR 0.66)明显更长。在多因素分析中,TIM-3高表达(50.8%)与RFSHR = 1.52)和OS较短(HR = 1.60)有显著关联。

CD3+ TILT细胞ICOS表达升高与良好的预后相关,而高TIM-3表达则提示预后不良。在应用PD-1阻滞剂以外,这项研究为改善ESCC预后提供了新见解。

原始出处:

Min Hee Hong. High CD3 and ICOS and low TIM-3 expression predict favourable survival in resected oesophageal squamous cell carcinoma. Sci Rep. 27 December 2019.

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    2020-10-02 cmsvly
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    2020-01-12 zhouqu_8
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    2020-01-10 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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