JAHA:睡眠呼吸暂停与血管加速老化有关

2021-07-26 MedSci原创 MedSci原创

这些数据支持OSA高风险个体的血管加速老化这一结论,其可能是OSA与心血管疾病之间相关性的潜在基础。

阻塞性睡眠呼吸暂停(OSA)与血管疾病之间相关性的潜在机制可能包括加速血管老化。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在比较高风险与低风险OSA患者的血管老化程度。


在2项基于社区的研究中,巴黎前瞻性研究3(PPS3)和马斯特里赫特研究,研究人员使用柏林问卷(OSA筛查问卷)确定了OSA的高风险程度,并评估了颈动脉特性(颈动脉内膜中层厚度、杨氏弹性模量、颈-股动脉脉搏波速度、颈动脉脉搏波速度、使用高精度超声回波图确定的颈动脉直径)和颈-股动脉脉搏波速度(仅在马斯特里赫特研究中)。研究人员使用多元线性回归估计了合并数据的回归系数。

睡眠呼吸暂停风险与血管加速老化的关系

该研究共纳入了8615名既往无心血管疾病的参与者(6840名来自PPS3研究,62%男性,平均年龄为59.5±6.2岁,1775名来自马斯特里赫特研究,51%男性,58.9±8.1岁)。总体而言,在PPS3和马斯特里赫特研究中,高风险OSA的患病率分别为16.8%(n=1150)和23.8%(n=423)。在调整年龄、性别、总胆固醇、吸烟、教育水平、糖尿病、心率和研究地区后,OSA高风险与较大的颈动脉内中膜厚度(β=0.21;0.17-0.26)、杨氏弹性模量(β=0.21;0.17-0.25)、颈-股动脉脉搏波速度(β=0.24;0.14-0.34)、颈动脉脉搏波速度(β=0.31;0.26–0.35)和颈动脉直径(β=0.43;0.38–0.48)相关。在对平均血压、体重指数或降压药物进行额外调整后,研究人员观察到了一致的关联。
 
由此可见,这些数据支持OSA高风险个体的血管加速老化这一结论,其可能是OSA与心血管疾病之间相关性的潜在基础。

原始出处:

Quentin Lisan.et al.Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community‐Based Cohort Studies.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.021318

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    2021-07-28 zhaohui6731
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