Nature子刊:相比中年,老年外科医生手术患者死亡风险反而升高14%!

2022-07-07 MedSci原创 MedSci原创

Scientifc Reports:外科医生年龄与术后并发症/死亡率的关系:队列研究的系统回顾和荟萃分析

过去25年来,全球卫生保健系统术后发病率和死亡率显著改善。然而,全世界每年有近420万人在手术后30天内死亡,是缺血性心脏病和中风之后的第三大死因。在发达国家,包括美国和加拿大,14.4%的外科患者中发生了不良事件。

既往研究表明病例数量增加和外科实践年限增加与健康结果的改善有关,例如复发率,围手术期并发症和死亡率。此外,在外科学习曲线中观察到平台期或成熟,其中病例数量和手术实践年限不再导致结局的显着改善。

外科手术人员和其他人口一样,正在老龄化。在美国,近三分之一的在职外科医生年龄超过55岁。同样,在澳大利亚,外科医生的平均年龄为52岁,19%的在职外科医生为65岁或以上。外科医生同样会经历与年龄相关的神经认知,感觉和运动功能的退化。这引起了人们对外科医生年龄与其手术结果之间关系的担忧,但外科医生的年龄与患者结果之间的关系尚未得到广泛研究。因此,本研究对对根据外科医生年龄进行的术后死亡率和主要发病率的队列研究进行了系统评价和荟萃分析。

检索于2021年2月使用Embase,Medline和CENTRAL数据库进行。以术后死亡率和主要发病率作为临床结局进行评估。研究人员将外科医生的年龄分为年轻,中年和老年外科医生,并比较了年轻和年长外科医生与中年外科医生的临床结果差异。

本研究最终纳入了10项回顾性队列研究,涉及1666108名患者的29类型不同手术。

死亡率

与中年外科医生相比,接受年轻外科医生手术的患者死亡率为1.02(1.00-1.04,p = 0.05)(I2= 40%)(图2A);接受老年外科医生手术的患者死亡率为1.14(1.02-1.28,p = 0.02)(I2= 80%)(图2B)。与年轻外科医生相比,接受老年外科医生手术的患者死亡率为1.23(0.93-1.63,p = 0.14)(I2= 85%)(图2C)。

主要并发症发生率

与中年外科医生相比,接受年轻外科医生手术的患者的主要并发症发生率为1.05(0.92-1.20,p = 0.48)(I2= 82%)(图3A),接受老年外科医生手术的患者的主要发病率为1.08(0.92-1.27,p = 0.34)(I2= 77%)(图3B)。与年轻外科医生相比,接受老年外科医生手术的患者的主要并发症发生率为1.00(0.83-1.21,p = 0.99)(I2= 88%)(图3C)。

根据大手术和小手术对主要并发症发病率进行了亚组分析。在亚组分析中,根据外科医生的年龄差异,未发现主要并发症的显着差异。表2为对结果的详细分析。

综上,与中年外科医生相比,接受老年外科医生手术的患者死亡率为1.14(1.02-1.28,p = 0.02)(I2= 80%)。虽然年轻外科医生进行的手术死亡率比中年外科医生的死亡率增加,但数据在统计学上并无差异。在主要并发症发病率和亚组分析中,根据外科医生的年龄分层并没有观察到显着差异。这项荟萃分析表明,老年外科医生进行的手术比中年外科医生的术后死亡风险更高。因此,有必要引入多学科方法来评估高级外科医生的表现。

 

原文来源:

Yeongin Jung, et al. Association between surgeon age and postoperative complications/ mortality: a systematic review and meta‑analysis of cohort studies. Scientifc Reports | (2022) 12:11251 | https://doi.org/10.1038/s41598-022-15275-7

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1885867, encodeId=7b25188586e19, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 23 21:01:34 CST 2023, time=2023-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983778, encodeId=4dfe1983e7868, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 25 08:01:34 CST 2022, time=2022-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256222, encodeId=803f125622260, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420760, encodeId=d2f91420e60f3, content=<a href='/topic/show?id=d2514292149' target=_blank style='color:#2F92EE;'>#外科医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42921, encryptionId=d2514292149, topicName=外科医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40a73606138, createdName=ysjykql, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=)]
    2023-02-23 liye789132251
  2. [GetPortalCommentsPageByObjectIdResponse(id=1885867, encodeId=7b25188586e19, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 23 21:01:34 CST 2023, time=2023-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983778, encodeId=4dfe1983e7868, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 25 08:01:34 CST 2022, time=2022-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256222, encodeId=803f125622260, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420760, encodeId=d2f91420e60f3, content=<a href='/topic/show?id=d2514292149' target=_blank style='color:#2F92EE;'>#外科医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42921, encryptionId=d2514292149, topicName=外科医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40a73606138, createdName=ysjykql, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1885867, encodeId=7b25188586e19, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 23 21:01:34 CST 2023, time=2023-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983778, encodeId=4dfe1983e7868, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 25 08:01:34 CST 2022, time=2022-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256222, encodeId=803f125622260, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420760, encodeId=d2f91420e60f3, content=<a href='/topic/show?id=d2514292149' target=_blank style='color:#2F92EE;'>#外科医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42921, encryptionId=d2514292149, topicName=外科医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40a73606138, createdName=ysjykql, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1885867, encodeId=7b25188586e19, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 23 21:01:34 CST 2023, time=2023-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983778, encodeId=4dfe1983e7868, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 25 08:01:34 CST 2022, time=2022-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256222, encodeId=803f125622260, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420760, encodeId=d2f91420e60f3, content=<a href='/topic/show?id=d2514292149' target=_blank style='color:#2F92EE;'>#外科医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42921, encryptionId=d2514292149, topicName=外科医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40a73606138, createdName=ysjykql, createdTime=Thu Jul 07 10:01:34 CST 2022, time=2022-07-07, status=1, ipAttribution=)]

相关资讯

GUT: 坏死性胆源性胰腺炎后胆囊切除术的超佳时机是出院后8周

胰腺炎是胰腺的炎症性疾病,是一种良性疾病,可以分为急性胰腺与慢性胰腺炎,按照病理类型分可分为水肿型胰腺炎,以及坏死性胰腺炎。

Lancet:手术过程中是否应该积极加温使患者的核心体温接近于正常体温?

手术过程中积极升温使患者体温升至37°C 的正常温度是否会改善患者预后?

JNNP:使用扩散成像预测颞叶癫痫手术结果

癫痫是50岁以上患者最常见的致残性神经系统疾病之一。颞叶癫痫(TLE)是最常见的局灶性癫痫,尽管服用抗癫痫药物进行治疗,但仍有约30%-40%的患者持续出现衰弱性癫痫发作。

CGH:自膨式金属支架治疗恶性远端胆道狭窄的效果优于塑料支架

胆管狭窄是由于胆管损伤和复发性胆管炎所致或是先天性而导致的胆管腔瘢痕性缩窄。胆管狭窄可由医源性损伤、腹部外伤和胆囊结石、胆管结石、胆管炎症等刺激,导致胆管壁纤维组织增生、管壁变厚、胆管内腔逐渐缩窄。

Heart:手术和经导管主动脉瓣置换术后感染性心内膜炎的风险

IE是接受SAVR和TAVI治疗患者罕见的并发症。在该研究人群中,SAVR后IE的发生率高于TAVI。

JAMA子刊:与综合医院相比,儿科专科医院在常规外科手术方面是否提供了更高的价值?

接受普通外科手术的儿童在CH和NCH具有相同的临床结果,但这些手术与较高的费用相关,因此,整体护理价值较低。