J Leukoc Biol:过敏性鼻炎患者中,白介素-5能够诱导CD4+T细胞凋亡缺陷

2019-02-21 Alex Yang MedSci原创

辅助性T细胞(Th)2极化在过敏性疾病的病理中具有重要的角色,而潜在的机制仍旧需要进一步的调查。类B细胞淋巴瘤蛋白-2蛋白12(Bcl2L12)具有抗凋亡的功能。最近,有研究人员阐释了过敏性鼻炎(AR)患者中,Bcl2L12对Th2极化的影响。研究发现,AR CD4+ T细胞(来源于AR患者)展现出了细胞凋亡的缺陷。FasL在AR CD4+ T细胞中表达要比HC(健康对照) CD4+ T细胞中更低

辅助性T细胞(Th)2极化在过敏性疾病的病理中具有重要的角色,而潜在的机制仍旧需要进一步的调查。类B细胞淋巴瘤蛋白-2蛋白12(Bcl2L12)具有抗凋亡的功能。最近,有研究人员阐释了过敏性鼻炎(AR)患者中,Bcl2L12对Th2极化的影响。

研究发现,AR CD4+ T细胞(来源于AR患者)展现出了细胞凋亡的缺陷。FasL在AR CD4+ T细胞中表达要比HC(健康对照) CD4+ T细胞中更低。血清IL-5水平与AR CD4+ T细胞中FasL的表达呈现负相关关系。CD4+ T细胞接触IL-5能够抑制FasL的表达,并增加Bcl2L12的表达。另外,IL-5能够增加CD4+ T细胞中Bcl2L12的表达,而Bcl2L12可以结合到FasL的启动子从而抑制FasL基因的转录。Bcl2L12的抑制能够恢复AR CD4+ T细胞中的细胞凋亡机制。

最后,研究人员指出,Bcl2L12在CD4+ T细胞中的过表达能够抑制细胞凋亡机制,而Bcl2L12的抑制能够恢复细胞凋亡机制。因此,CD4+ T细胞中的Bcl2L12可能是治疗AR和其他过敏性障碍的一个新的靶标。

原始出处:

Luo XQ, Ma F, Wang S et al. Interleukin-5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis. J Leukoc Biol. 29 Jan 2019.

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    2019-10-04 xuyu
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    2019-03-25 sunylz
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level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372121, encodeId=78cc13e2121fb, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500972, encodeId=059015009e294, content=<a href='/topic/show?id=04794329fc' target=_blank style='color:#2F92EE;'>#CD4+T细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4329, encryptionId=04794329fc, topicName=CD4+T细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd149483945, createdName=海豹, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361190, encodeId=de6f36119066, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Feb 21 13:02:02 CST 2019, time=2019-02-21, status=1, ipAttribution=)]
    2019-03-06 qidongfanjian
  5. 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topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Wed Mar 06 23:56:00 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767615, encodeId=23ff1e676152e, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sun Oct 20 23:56:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340293, encodeId=8516134029341, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372121, encodeId=78cc13e2121fb, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500972, encodeId=059015009e294, content=<a href='/topic/show?id=04794329fc' target=_blank style='color:#2F92EE;'>#CD4+T细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4329, encryptionId=04794329fc, topicName=CD4+T细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd149483945, createdName=海豹, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361190, encodeId=de6f36119066, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Feb 21 13:02:02 CST 2019, time=2019-02-21, status=1, ipAttribution=)]
  6. 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level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372121, encodeId=78cc13e2121fb, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Feb 23 03:56:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), 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createdTime=Thu Feb 21 13:02:02 CST 2019, time=2019-02-21, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1652595, encodeId=45551652595b2, content=<a href='/topic/show?id=5082432634' target=_blank style='color:#2F92EE;'>#CD4+#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4326, encryptionId=5082432634, topicName=CD4+)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4c1624305102, createdName=xuyu, createdTime=Fri Oct 04 22:56:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918550, encodeId=ffc31918550fd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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createdTime=Thu Feb 21 13:02:02 CST 2019, time=2019-02-21, status=1, ipAttribution=)]
  8. 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createdTime=Thu Feb 21 13:02:02 CST 2019, time=2019-02-21, status=1, ipAttribution=)]
    2019-02-21 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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