JAMA Pediatr:影响儿童血铅水平的个人及社会因素研究

2021-09-28 MedSci原创 MedSci原创

研究认为影响儿童血铅水平的因素包括个人及社会2方面,其中贫困及种族是最主要的因素

铅元素在人体内没有生物学作用。血铅阳性,无论程度如何都是异常和潜在有害的,特别是儿童。目前尚无儿童铅接触的安全阈值,主要文献认定超过5.0μg/dl为血铅水平升高(BLLs)。近日研究人员考察了与美国儿童血铅水平相关的个人和社区因素。

本次横断面回顾性研究分析了2018年10月1日至2020年2月29日期间一家大型临床实验室进行的血铅检测结果。参与者为1141441名6岁以下儿童,来自美国50个州和哥伦比亚特区,收集参与者个人人口统计数据,包括性别、年龄和保险类型;社区人口数据包括20世纪50年代以前的住房、贫困、主要种族和族裔以及地理区域等。研究的主要终点为血铅水平,定义血铅水平≥1.0 μg/dL为血铅阳性,≥5.0μg/dL为BLLs。

参与儿童中,男孩586703名,平均年龄2.3岁,超过一半的儿童血铅阳性(576092人,50.5%),21172 名儿童为BLLs (1.9%)。在多变量分析中,有公共保险的儿童血铅阳性(调整后的优势比[AOR]:2.01)和BLLs(AOR:1.08)的几率更大。居住在20世纪50年代前的住房(血铅阳性AOR=1.65,BLLs AOR=3.06)和最贫困五分之一(血铅阳性AOR=1.89;BLLs AOR=1.99)儿童的血铅阳性和BLLs风险较高。黑人、非西班牙裔和非拉美裔儿童血铅阳性的风险较高(AOR=1.13),但BLL风险未见显著增加(AOR=0.83)。

全美各州儿童血铅阳性率

研究认为影响儿童血铅水平的因素包括个人及社会2方面,其中贫困及种族是最主要的因素

原始出处:

Marissa Hauptman et al. Individual- and Community-Level Factors Associated With Detectable and Elevated Blood Lead Levels in US Children Results From a National Clinical Laboratory. JAMA Pediatr. September 27, 2021.

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    2022-09-06 feather89
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    2021-09-29 13f0c37dm61暂无昵称

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    2021-09-28 查查佳佳

    拉头继续教育可能吗丁啉~TM卡号

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