AP&T: 患有非酒精性脂肪肝的肥胖和非肥胖受试者的脂质组学的改变

2020-10-29 MedSci原创 MedSci原创

非酒精性脂肪肝疾病(NAFLD)是由肝甘油三酸酯(TGs)的异常积累引起的,这被称为单纯脂肪变性,有时可能会发展为非酒精性脂肪性肝炎(NASH)。

        非酒精性脂肪肝疾病(NAFLD)是由肝甘油三酸酯(TGs)的异常积累引起的,这被称为单纯脂肪变性,有时可能会发展为非酒精性脂肪性肝炎(NASH)和相关的纤维化。虽然肝甘油三酯的过度积累是已知的引发NAFLD的危险因素,但是尚不清楚非肥胖非酒精性脂肪性肝炎(NASH)的潜在机制,因此,本项研究旨在尝试使用脂质组学方法确定与非肥胖和肥胖NAFLD相关的代谢紊乱的相关性。

 

        研究人员对361名经活检证实的NAFLD(157名NAFL和138名NASH)和健康对照组(n = 66)进行了横断面分析。根据亚洲人的体重指数,将其分为肥胖或非肥胖。根据NAFLD的组织学严重程度进行循环血脂分析。使用独立的验证集(154名NAFLD受试者[93名NAFL和61名NASH]和21名健康对照)验证了循环脂质组学改变。

 

        在非肥胖的NAFLD患者中,饱和的鞘磷脂(SM)与内脏肥胖显着相关(SM d38:0;P  <0.001),而在肥胖的NAFLD中则没有。此外,SM水平与全身和脂肪组织的胰岛素抵抗显着相关(SM d38:0;P<0.001)。选择了非肥胖受试者的五种潜在脂质代谢物和肥胖受试者的七种潜在脂质来预测NAFLD和NASH。这些脂质组合对于非肥胖(NAFLD / NASH = 0.916 / 0.813的曲线下面积[AUC])和肥胖症(NAFLD / NASH = 0.967 / 0.812的AUC)表现出良好的诊断性能。

 

        本项研究最后作者说道:非肥胖和肥胖的NAFLD受试者表现出独特的循环脂质组学特征,包括甘油二脂(DAG),甘油三酯(TAG)和鞘磷脂(SM)的差异。这些脂质组合对于非肥胖和肥胖的NAFLD患者可能是有用的生物标志物。

 

 

原始出处:

Youngae Jung. Et al. Circulating lipidomic alterations in obese and non‐obese subjects with non‐alcoholic fatty liver disease. Alimentary Pharmacology and Therapeutics.2020.

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