J Periodon Res:lncRNA MALAT1通过sponging miR-20a和激活TLR4通路调节脂多糖刺激的人牙龈成纤维细胞炎症细胞因子的产生

2020-03-31 网络 网络

长非编码RNA(lnc RNAs),如肺腺癌转移相关转录因子 1 (MALAT1),是炎症性疾病发展的关键调节因子。 然而,目前尚不清楚MALAT1是否调节人牙龈成纤维细胞(HGFs)在牙周炎中的作用

长非编码RNA(lnc RNAs),如肺腺癌转移相关转录因子 1 (MALAT1),是炎症性疾病发展的关键调节因子。 然而,目前尚不清楚MALAT1是否调节人牙龈成纤维细胞(HGFs)在牙周炎中的作用。 本研究旨在探讨MALAT1对HGFS炎性细胞因子产生的作用。

从人牙龈中获取原代HGFs,通过定量实时PCR(qRT-PCR)检测炎症和健康牙龈组织中的MALAT1。 采用生物信息学分析、双荧光素酶报告法和RNA结合蛋白免疫沉淀法(RIP)检测MALAT1、Toll样受体4(TLR4)和microRNA(miR)-20a之间的关系。 HGFs转染MALAT1 siRNA (si‐MALAT1), miR‐20a mimic 或MALAT1 过表达质粒(sno‐MALAT1)后,LPS处理,采用qRT-PCR、酶联免疫吸附试验或western blot法分析MALAT1、miR-20a、TLR4、IL-6和IL-8的水平。

MALAT1在慢性牙周炎的炎性牙龈组织中上调。 在RNA-蛋白复合物与Ago2中,miR-20a分别与MALAT1和TLR43α-UTR结合。 此外,MALAT1、TLR4、IL-6和IL-8在1μg/ml牙龈卟啉单胞菌脂多糖(LPS)或大肠杆菌LPS刺激后增加,而miR-20a下降。miR-20a通过与TLR4 3'-UTR结合抑制促炎细胞因子的表达。 MALAT1还增加了TLR4的水平和炎性细胞因子的分泌。

MALAT1通过sponging miR-20a和释放TLR4增强炎症细胞因子的产生,表明MALAT1在牙周炎中具有调节作用。

原始出处:

Jiashan Li, LncRNA MALAT1 regulates inflammatory cytokine production in lipopolysaccharide‐stimulated human gingival fibroblasts through sponging miR‐20a and activating TLR4 pathway. Journal of periodontal research, 2020 March. Doi:10.1111/jre.12700

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    2020-10-20 lilianxiang
  4. [GetPortalCommentsPageByObjectIdResponse(id=2005725, encodeId=2b5f2005e25ac, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Fri Mar 05 12:29:40 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809612, encodeId=c529180961201, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=2005725, encodeId=2b5f2005e25ac, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Fri Mar 05 12:29:40 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809612, encodeId=c529180961201, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, 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createdName=ms1292405679162969, createdTime=Sat Jun 13 22:29:40 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077081, encodeId=4e9020e708145, content=<a href='/topic/show?id=955d226045' target=_blank style='color:#2F92EE;'>#ALA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2260, encryptionId=955d226045, topicName=ALA)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/lGEyfsKnIkkH93xUPMrUUycLh2XOfJJsphwPsVqDx8somSOepIFy9QE0MVAwDW3AS7V1epJ4tbPL9ADJLicvm8A/132, createdBy=b5132500067, createdName=ms55066533437992, createdTime=Sun Sep 20 13:29:40 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930768, encodeId=7e261930e6806, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Thu Dec 17 07:29:40 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053612, encodeId=14f9205361211, content=<a href='/topic/show?id=f84e6e055ab' target=_blank style='color:#2F92EE;'>#炎症细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67055, encryptionId=f84e6e055ab, topicName=炎症细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03e7496, createdName=楚钟, createdTime=Fri Oct 02 06:29:40 CST 2020, time=2020-10-02, status=1, ipAttribution=)]
    2020-11-07 feather89
  6. 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createdName=ms1292405679162969, createdTime=Sat Jun 13 22:29:40 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077081, encodeId=4e9020e708145, content=<a href='/topic/show?id=955d226045' target=_blank style='color:#2F92EE;'>#ALA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2260, encryptionId=955d226045, topicName=ALA)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/lGEyfsKnIkkH93xUPMrUUycLh2XOfJJsphwPsVqDx8somSOepIFy9QE0MVAwDW3AS7V1epJ4tbPL9ADJLicvm8A/132, createdBy=b5132500067, createdName=ms55066533437992, createdTime=Sun Sep 20 13:29:40 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930768, encodeId=7e261930e6806, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, 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  7. 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  8. 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  9. 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    2020-12-17 smallant2002
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