JNNP:健康缺陷累积、载脂蛋白E基因型和晚年轻度认知障碍和痴呆的风险

2020-11-27 MedSci原创 MedSci原创

健康的生活方式与晚年罹患痴呆症的风险降低相关。通过检查与年龄相关的健康缺陷的积累或测量脆弱程度,还可以观察总体健康如何影响痴呆症的风险。衰弱是一种与年龄相关的健康状态,与不良事件,痴呆和死亡的风险增加

健康的生活方式与晚年罹患痴呆症的风险降低相关。通过检查与年龄相关的健康缺陷的积累或测量脆弱程度,还可以观察总体健康如何影响痴呆症的风险。衰弱是一种与年龄相关的健康状态,与不良事件,痴呆和死亡的风险增加相关。测量每个人的衰弱程度可能有助于识别那些没有认知障碍的人最有可能发展为轻度认知功能障碍MCI。研究APOE基因型与健康缺陷累积是否独立于轻度认知功能障碍(MCI)和痴呆的危险性。

方法:数据由位于美国各地的老年痴呆症疾病研究中心(ADRC)提供。采用缺陷累积法计算50岁以上老年痴呆症患者的虚弱指数。认知状态通过临床评估确定。利用多状态转换模型,我们评估了虚弱程度的增加对非认知障碍(NCI)、MCI和痴呆之间转换概率的影响程度。参与者包括患有MCI和阿尔茨海默氏病及相关疾病的人,以及一部分健康志愿者。自2005年以来,这些ADRC通过对受试者进行的前瞻性,标准化和纵向临床评估收集了数据,形成了统一数据集(UDS)。对于UDS,基线和后续随访数据(大约每年一次)由临床医生和诊所工作人员收集,并包含有关参与者的社会人口统计学,神经系统检查结果,功能状态,神经心理测试结果,临床诊断和APOE基因型的不确定信息。

结果:受试者(n=14 490)平均年龄72.2岁(标准偏差=8.9岁;范围=50-103岁)。在基线时的NCI中(n=9773),虚弱指数每增加0.1,就有较高的MCI发生风险和更高的发展为痴呆症的风险。在基线检查时有MCI的患者(n=4717),虚弱程度越高,进展为痴呆症的风险越高,被重新分类为NCI的可能性越低,重新分类为NCI的可能性也越高。这些风险效应在载脂蛋白eε4等位基因携带者和非携带者中都存在并相似。

结论:虚弱是老年性认知功能障碍和痴呆症的一个关键危险因素,它既是预防年龄相关认知障碍干预措施的目标,也是MCI患者可能的预后标志。这项研究支持了一种新的概念,即晚发性痴呆症是一种复杂的衰老结果,通常与个人的总体健康以及遗传风险因素密切相关。在美国老年人中,健康缺陷的累积影响进行性认知损害的可能性和认知改善的可能性,独立于痴呆症的强烈遗传危险因素。虚弱是认知功能障碍的一个重要危险因素,也是潜在预后价值的标志。

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    2020-11-27 392534278

    学习

    0

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time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902681, encodeId=b7c690268150, content=虚弱是老年性认知功能障碍和痴呆症的一个关键危险因素,它既是预防年龄相关认知障碍干预措施的目标,也是MCI患者可能的预后标志, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Fri Nov 27 08:15:42 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902666, encodeId=49319026664f, content=`好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Fri Nov 27 07:15:17 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902665, encodeId=7202902665ac, content=如, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Fri Nov 27 07:15:12 CST 2020, time=2020-11-27, status=1, ipAttribution=)]
    2020-11-27 Jessica

    虚弱是老年性认知功能障碍和痴呆症的一个关键危险因素,虚弱指数每增加0.1,就有较高的MCI发生风险和更高的发展为痴呆症的风险。虚弱程度越高,进展为痴呆症的风险越高。#老年痴呆#

    0

  8. 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time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902681, encodeId=b7c690268150, content=虚弱是老年性认知功能障碍和痴呆症的一个关键危险因素,它既是预防年龄相关认知障碍干预措施的目标,也是MCI患者可能的预后标志, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Fri Nov 27 08:15:42 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902666, encodeId=49319026664f, content=`好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Fri Nov 27 07:15:17 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902665, encodeId=7202902665ac, content=如, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Fri Nov 27 07:15:12 CST 2020, time=2020-11-27, status=1, ipAttribution=)]
    2020-11-27 Oranhyg

    虚弱是老年性认知功能障碍和痴呆症的一个关键危险因素,它既是预防年龄相关认知障碍干预措施的目标,也是MCI患者可能的预后标志

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902665, encodeId=7202902665ac, content=如, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Fri Nov 27 07:15:12 CST 2020, time=2020-11-27, status=1, ipAttribution=)]
    2020-11-27 thm112988

    `好

    0

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    2020-11-27 thm112988

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