Gastroenterology:含硫微生物饮食与早发性结直肠癌风险增加有关

2021-07-20 MedSci原创 MedSci原创

不健康的饮食模式可能会导致患者50 岁之前结直肠癌 (CRC) 的发病率增加(即早发性 CRC)。

      不健康的饮食模式可能会导致患者50 岁之前结直肠癌 (CRC) 的发病率增加(即早发性 CRC)。因为膳食中含硫的微生物代谢会产生硫化氢 (H 2 S),这是一种难以大规模测量的胃肠道致癌物。因此,目前还缺乏支持其在早期肿瘤形成中作用的证据。

 

      研究人员为此评估了患者对硫微生物饮食的长期依从性,这是一种基于与硫代谢相关的 43 种细菌种类增加的饮食指数,本项研究作为一项前瞻性队列研究,所纳入的接受内窥镜检查的 59013 名患者中均具有 CRC 风险,每四年通过经过验证的食物频率问卷和 1998 年青春期膳食摄入量评估进行患者的膳食评估。

 

      研究结果显示所有患者出现了 2911 例早发性腺瘤病例。在调整已确定的风险因素后,较高的硫微生物饮食评分与早发性腺瘤的风险增加有关(OR Q4vs.Q1 = 1.31,95 % CI:1.10 至 1.56,P=0.02),但与锯齿状病变无关。与最低四分位数相比,硫微生物饮食评分最高四分位数的女性患具有更大恶性潜能的早发性腺瘤的风险显着增加(OR Q4vs.Q1 =1.65,95% CI:1.12 至 2.43;P=0.04),但是50 岁以后腺瘤的发生与饮食没有明确的关联。

 

      本项研究证实年轻女性中的饮食与肠道硫代谢细菌的相互作用在早发性结直肠癌的发生中扮演重要作用。

 

 

原始出处 :

Long H.Nguyen. Et al. The sulfur microbial diet is associated with increased risk of early-onset colorectal cancer precursors. Gastroenterology.2021.

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createdName=chaojitidian, createdTime=Thu Jul 22 03:34:22 CST 2021, time=2021-07-22, status=1, ipAttribution=)]
  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Jul 29 13:34:22 CST 2021, time=2021-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073391, encodeId=c2da20e339102, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Feb 14 06:34:22 CST 2022, time=2022-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453550, encodeId=a55b1453550b8, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Jul 22 03:34:22 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505295, encodeId=d47315052953c, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Jul 22 03:34:22 CST 2021, time=2021-07-22, status=1, ipAttribution=)]
    2022-06-18 sjq027
  6. 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createdName=chaojitidian, createdTime=Thu Jul 22 03:34:22 CST 2021, time=2021-07-22, status=1, ipAttribution=)]
  7. 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encodeId=a55b1453550b8, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Jul 22 03:34:22 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505295, encodeId=d47315052953c, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Jul 22 03:34:22 CST 2021, time=2021-07-22, status=1, ipAttribution=)]
    2022-02-14 许安
  8. 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