PLOS ONE:血糖浓度升高改变胚胎代谢组学特征

2018-06-22 海北 MedSci原创

慢性高血糖浓度是糖尿病的一个特征。已有的研究显示,孕产妇糖尿病会影响早期胚胎的代谢并可能导致发育迟缓。

慢性高血糖浓度是糖尿病的一个特征。已有的研究显示,孕产妇糖尿病会影响早期胚胎的代谢并可能导致发育迟缓。为了模拟母体糖尿病,研究人员分别在含有0.5235mM葡萄糖的受精培养基和培养基中进行牛体外受精和胚胎培养,而在对照条件下,培养基不含葡萄糖(0mM)。

研究人员发现,与对照条件(0mM31%)相比,用0.52mM葡萄糖培养将囊胚发育降低至23%。培养基中存在35 mM葡萄糖会导致囊胚率降低(分别为20%和10%)。此外,研究人员还通过UPLC-MS / MS分析得到的第8天囊胚的代谢组特征,并与对照条件下培养的囊胚进行比较。他们发现,葡萄糖浓度升高刺激糖酵解的增加,以及参与蛋白质糖基化的己糖胺途径的活性。然而,三羧酸循环的组分,如柠檬酸盐和α-酮戊二酸,在葡萄糖刺激的囊胚中减少,表明来自丙酮酸的能量产生是低效的。另一方面,多元醇途径的活性增加,其为能源生产的替代途径。

简言之,如果在早期发育过程中暴露于升高的葡萄糖浓度,牛胚胎显示出了代谢组学的变化,与暴露于糖尿病状况的预期一致。


原始出处:
Uhde K et al. Exposure to elevated glucose concentrations alters the metabolomic profile of bovine blastocysts. PLOS ONE, 2018; DOI: 10.1371/journal.pone.0199310

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  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:48 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326312, encodeId=420932631279, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:40 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326311, encodeId=cdf432631118, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, 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level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:19 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-06-23 Y—xianghai

    学习了长知识

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:48 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326312, encodeId=420932631279, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:40 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326311, encodeId=cdf432631118, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, 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level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:19 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-06-23 Y—xianghai

    学习了长知识

    0

  7. 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    2018-06-23 Y—xianghai

    学习了长知识

    0

  8. 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level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:19 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-06-23 Y—xianghai

    学习了长知识

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1790225, encodeId=f4981e9022536, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Jun 30 23:52:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315396, encodeId=750113153965b, content=<a href='/topic/show?id=6fcc83e0554' target=_blank style='color:#2F92EE;'>#胚胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83705, encryptionId=6fcc83e0554, topicName=胚胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:48 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326312, encodeId=420932631279, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:40 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326311, encodeId=cdf432631118, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, 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level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:19 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-06-23 Y—xianghai

    学习了长知识

    0

  10. 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level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 23 08:02:19 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-06-23 Y—xianghai

    学习了长知识

    0

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最近的研究指出了表观遗传机制在牙周炎和2型糖尿病(DM)等多因子疾病发展中的关键作用。此外,microRNA(miR)已成为各种疾病的新型生物标志物。本研究的目的是探讨含(CPDM)和不含DM 2型(CP)牙周炎患者或牙周健康者(对照组,分别为PHDM和PH)的龈沟液(GCF)中miR-146a和miR-155水平以及超氧化物歧化酶(SOD)。使用实时定量PCR分析miR调节,,分光光度法测量SO

JACC:健康的生活方式可降低糖尿病患者心血管风险

目前,关于生活方式对糖尿病患者心血管疾病发生的影响尚属未知。本研究的目的旨在评估2型糖尿病患者良好的生活方式与其心血管疾病发生率和死亡率的关系。本研究纳入了11527名2型糖尿病患者(女性占8970名),所有患者在诊断糖尿病时均无心血管疾病和癌症。良好的生活方式包括高质量饮食、无烟、中等强度的体育锻炼((≥150min/周)和适当饮酒(女性5-15g/天;男性5-30g/天)。经过平均13.3年时