Semin Arthritis Rheu:抗风湿治疗期间的急性呼吸道病毒感染

2020-07-25 xiangting MedSci原创

该研究发现某些药物会增加急性呼吸道病毒感染的风险。

COVID-19是一种急性呼吸道病毒感染,对全世界都存在威胁,其中包括风湿病患者。但是抗风湿治疗在多大程度上会增加患者对病毒性呼吸道感染的易感性目前尚不清楚。

这项研究对与抗风湿治疗相关的急性呼吸道病毒不良事件的发生率和严重性进行了回顾。

使用在线数据库查找报道抗风湿治疗患者急性呼吸道病毒感染主要数据的研究。独立审阅者使用标准化数据提取工具对符合条件的研究的图表数据进行配对。

共有180项研究符合定性分析的条件。尽管现有文献在报道急性病毒感染或其并发症方面缺乏特异性,但数据表明使用糖皮质激素、JAK抑制剂(尤其是大剂量)、TNF抑制剂和抗IL-17药物与呼吸道病毒感染事件的发生率升高相关。现有数据表明,使用NSAIDs、羟氯喹、柳氮磺胺吡啶、甲氨蝶呤、硫唑嘌呤、霉酚酸酯、环磷酰胺或阿普斯特不会增加呼吸道病毒事件的发生率或风险。一项大型队列研究表明,与不使用相比,使用来氟米特与急性病毒性呼吸道事件的风险升高相关。

该研究发现某些药物会增加急性呼吸道病毒感染的风险。但是,缺乏确切的数据,未来的研究应解决这一知识鸿沟。

原始出处:

Adam Kilian. Acute respiratory viral adverse events during use of antirheumatic disease therapies: a scoping review. Semin Arthritis Rheu. 22 July 2020.

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