NEJM：Covid-19疫苗对Delta变异病毒到底有效吗？证据来了！

2021-08-12 MedSci原创 MedSci原创

在接受两剂疫苗接种后，与alpha变异病毒相比，疫苗对delta变异病毒的有效性仅存在一定差异。接种第一剂疫苗后，疫苗有效性的绝对差异更为明显。这一发现将支持在易感人群中最大限度地接种两剂疫苗。

严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)的B.1.617.2(delta)变异病毒，是导致印度Covid-19病例激增的主要原因，并导致在全球范围内扩散，包括英国的病例显著增加。BNT162b2和ChAdOx1nCoV-19疫苗对该delta变异病毒的有效性尚未明确。近日，顶级医学期刊NEJM上发表了一篇研究文章，研究人员使用核酸检测阴性的病例对照设计来估计在delta变异病毒开始传播期间针对由delta变异病毒或优势菌株（B.1.1.7或alpha变体）引起的有症状疾病的疫苗接种的有效性。研究人员使用测序并根据刺突(S)基因状态确定变异病毒。根据患者的疫苗接种状态，使用英格兰所有有症状的Covid-19序列病例的数据来估计具有任一变异病毒的病例比例。接种一剂疫苗（BNT162b2或ChAdOx1nCoV-19）后对delta变异病毒的有效性（30.7%；95%置信区间[CI]为25.2至35.7）明显低于alpha变异病毒（48.7%；95%CI为45.5至51.7)；两种疫苗的结果相似。使用BNT162b2疫苗，对于alpha变异病毒，接种两剂疫苗的有效性为

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#插入话题

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2022-04-04 lixiaol

#变异病毒#

32 0
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2021-08-14 12498dabm77暂无昵称

#变异#

25 0
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2021-08-12 旺医

顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

38 0
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2021-08-12 小小的丁香花

支持接种

52 0