Anesth Analg :研究表明,阿司匹林可以降低COVID-19住院患者的死亡风险

2020-10-25 生物世界 Bio生物世界

阿司匹林(Aspirin)自发明以来已有100多年历史,如今的它作为一种解热镇痛药已然走进千家万户。越来越多的研究表明阿司匹林对神经退行性疾病、癌症等重大疾病也有着一定的预防和治疗效用。

阿司匹林(Aspirin)自发明以来已有100多年历史,如今的它作为一种解热镇痛药已然走进千家万户。令人惊讶的是,近年来科学家意外地发现阿司匹林的功效远不止于此,越来越多的研究表明阿司匹林对神经退行性疾病、癌症等重大疾病也有着一定的预防和治疗效用。

2020年10月21日,美国马里兰大学医学院的研究人员在 Anesthesia & Analgesia 上发表题为:Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19 的研究论文。

这项研究发现,在住院治疗的COVID-19患者中,为预防血管疾病而每天服用低剂量阿司匹林的患者相比于那些不服用阿司匹林的患者,前者的新冠并发症和死亡风险将显着降低。这预示着阿司匹林将是一种安全、有效和便宜的新冠预防药物。

如今,新冠疫情仍然丝毫未见消退的迹象,更可怕的是,近日以来,随着北半球逐渐步入秋冬季节,欧洲等地区的疫情再次出现反弹现象,与此同时,美国、印度和巴西等国家的疫情形势也未见好转。

由此看来,抗击新冠疫情必将是一场持久战,因而开发一些安全、有效且便宜的新冠预防和治疗方案十分必要的。

在此项研究中,研究团队首先筛选了412名COVID-19住院患者的医疗记录,这些患者平均年龄为55岁,在过去几个月因感染并发症住院。值得注意的是,约有四分之一的患者在住院前后每天服用低剂量的阿司匹林(通常为81mg),以预防控制心血管疾病。

412名COVID-19住院患者的医疗记录

研究人员发现,每天服用低剂量阿司匹林可以有效降低使用呼吸机的风险——降低了44%,且与不服用阿司匹林的患者相比,在ICU住院的风险降低了43%。最重要的是,患者住院死亡的风险降低了47%,并且大出血等不良事件的发生率没有显着增加。

每天服用低剂量阿司匹林可以有效降低COVID-19患者的重症转化率

为了进一步提高研究结果的说服力,研究人员控制了几个可能在病人预后中起作用的因素,包括年龄、性别、体重指数、种族、高血压和糖尿病。此外,心脏病、肾脏疾病、肝脏疾病以及使用受体阻滞剂来控制血压也与这些疾病有关。

服用阿司匹林患者与不服用阿司匹林患者的比较

那么,为什么服用阿司匹林能够有效降低COVID-19患者的重症转化率呢?

实际上,COVID-19感染会增加心脏、肺、血管以及其他器官的血栓形成,并且在极少数情况下,由血栓引起的并发症会导致心脏病发作、中风、多器官衰竭甚至死亡。

与此同时,在临床上,医生常常建议那些曾经因血栓引起心脏病发作或中风的患者每天服用低剂量阿司匹林,以防止以后再发生血栓。当然,每天服用阿司匹林也会增加大出血或消化性溃疡疾病的风险。

Nature News 报道——“重症COVID-19患者凝血之谜,迫使新疗法的开发”

“我们认为,阿司匹林可以防止微小血凝块的形成,从而为COVID-19患者提供了意想不到的益处,”文章的合着者、UMSOM大学麻醉学副教授Michael A. Mazzeffi博士说道:“确诊为COVID-19的患者可以考虑每天服用阿司匹林,只要他们先与医生确认。”

当然,并不是所有COVID-19患者都能使用该疗法。例如,那些因慢性肾病而出血风险增加的人,或者因为他们经常使用某些药物——如类固醇或血液稀释剂,可能无法安全地服用阿司匹林。

但不管怎么说,这是一个十分关键的发现,并值得进一步的随机临床试验来确认。对此,文章的第一作者Jonathan Chow博士说表示:“如果我们的发现得到证实,它将使阿司匹林成为首个广泛使用的降低COVID-19患者死亡率的非处方药物。”

原始出处:

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy,et al.Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19.Anesth Analg. 2020 Oct 21. doi: 10.1213/ANE.0000000000005292.

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    2021-07-07 经常头晕
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style='color:#2F92EE;'>#阿司匹林#</a>可以防止微小血凝块的形成,从而为COVID-19患者提供了意想不到的益处。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:09 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894421, encodeId=bce78944217d, content=这个研究厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:32:11 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894382, encodeId=aca18943827f, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Oct 25 20:04:43 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894380, encodeId=dc7e8943809b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Sun Oct 25 19:55:10 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-12-23 AspirantSuo
  4. [GetPortalCommentsPageByObjectIdResponse(id=2051617, encodeId=0e6d205161e68, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Apr 30 12:32:07 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700122, encodeId=eea71e0012215, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Wed Jul 07 22:32:07 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633593, encodeId=32b8163359356, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Wed Dec 23 21:32:07 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256029, encodeId=c7a012560290e, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Oct 27 07:32:07 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894576, encodeId=ee0a8945e6b4, content=COVID-19感染会增加心脏、肺、血管以及其他器官的血栓形成,并且在极少数情况下,由血栓引起的并发症会导致心脏病发作、中风、多器官衰竭甚至死亡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:33 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894575, encodeId=27e88945e5e8, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>可以防止微小血凝块的形成,从而为COVID-19患者提供了意想不到的益处。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:09 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894421, encodeId=bce78944217d, content=这个研究厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:32:11 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894382, encodeId=aca18943827f, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Oct 25 20:04:43 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894380, encodeId=dc7e8943809b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Sun Oct 25 19:55:10 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
  5. 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topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Oct 27 07:32:07 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894576, encodeId=ee0a8945e6b4, content=COVID-19感染会增加心脏、肺、血管以及其他器官的血栓形成,并且在极少数情况下,由血栓引起的并发症会导致心脏病发作、中风、多器官衰竭甚至死亡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:33 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894575, encodeId=27e88945e5e8, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>可以防止微小血凝块的形成,从而为COVID-19患者提供了意想不到的益处。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:09 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894421, encodeId=bce78944217d, content=这个研究厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:32:11 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894382, encodeId=aca18943827f, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Oct 25 20:04:43 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894380, encodeId=dc7e8943809b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Sun Oct 25 19:55:10 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-10-26 Jessica

    COVID-19感染会增加心脏、肺、血管以及其他器官的血栓形成,并且在极少数情况下,由血栓引起的并发症会导致心脏病发作、中风、多器官衰竭甚至死亡。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2051617, encodeId=0e6d205161e68, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Apr 30 12:32:07 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700122, encodeId=eea71e0012215, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Wed Jul 07 22:32:07 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633593, encodeId=32b8163359356, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Wed Dec 23 21:32:07 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256029, encodeId=c7a012560290e, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Oct 27 07:32:07 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894576, encodeId=ee0a8945e6b4, content=COVID-19感染会增加心脏、肺、血管以及其他器官的血栓形成,并且在极少数情况下,由血栓引起的并发症会导致心脏病发作、中风、多器官衰竭甚至死亡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:33 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894575, encodeId=27e88945e5e8, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>可以防止微小血凝块的形成,从而为COVID-19患者提供了意想不到的益处。, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:36:09 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894421, encodeId=bce78944217d, content=这个研究厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:32:11 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894382, encodeId=aca18943827f, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Oct 25 20:04:43 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894380, encodeId=dc7e8943809b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Sun Oct 25 19:55:10 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-10-26 Jessica

    #阿司匹林#可以防止微小血凝块的形成,从而为COVID-19患者提供了意想不到的益处。

    0

  7. 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createdTime=Sun Oct 25 22:32:11 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894382, encodeId=aca18943827f, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Oct 25 20:04:43 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894380, encodeId=dc7e8943809b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2020-10-25 narutohokage

    这个研究厉害

    0

  8. 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    2020-10-25 易水河

    学习学习

    0

  9. 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    2020-10-25 清幽蓝燕yan

    学习了

    0

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