肥胖越久,心脏越易受伤

2018-02-23 张思玮 中国科学报

超重或肥胖的年数会“叠加”成为一个独特的风险因素,使心脏损伤更容易发生。这是约翰·霍普金斯大学的研究人员历经30多年,通过对9000多人的临床数据分析得出来的结论,相关研究成果已经发表在近期的《临床化学》杂志(Clinical Chemistry)上。“即使在没有诸如高血压、糖尿病或肾脏疾病等心脏疾病风险因素的情况下,肥胖或超重的年数也会影响心脏损伤的风险。”约翰·霍普金斯大学医学院的Robert

超重或肥胖的年数会“叠加”成为一个独特的风险因素,使心脏损伤更容易发生。这是约翰·霍普金斯大学的研究人员历经30多年,通过对9000多人的临床数据分析得出来的结论,相关研究成果已经发表在近期的《临床化学》杂志(Clinical Chemistry)上。

“即使在没有诸如高血压糖尿病或肾脏疾病等心脏疾病风险因素的情况下,肥胖或超重的年数也会影响心脏损伤的风险。”约翰·霍普金斯大学医学院的Robert E. Meyerhoff助理教授及约翰·霍普金斯Ciccarone心脏病预防中心的成员Chiadi Ndumele表示。

其实,早在2014年,Ndumele及其同事就发现了,体重超重与沉默(无症状)心脏损伤有关, 但该研究并未评估长时间超重的影响。

鉴于此,研究人员使用了从1987年到1989年招募的9062名研究参与者的数据,这些研究参与者从1998年开始接受了四次访问,以对其下列健康指标进行评估:身体质量指数(BMI)、心脏病史以及血液中的高敏感性肌钙蛋白的水平。从第一次访问到第四次访问,将近23%的参与者的BMI有所增加。一个人的BMI每平方米超过25千克为超重,BMI超过30为肥胖。在第四次访问时,共有3748人超重,3184人肥胖。另外,大约5%的参与者的BMI下降,而72%的人保持不变。

在第四次访问中,将近7%的参与者(623人)的肌钙蛋白水平升高至14纳克每升或更高。而那些在第四次访问时体重指数增加至超重和肥胖范围的患者,有1.5倍的可能性其肌钙蛋白水平会增加到显示其心脏受损的至少14纳克每升的水平。

随后,专家们研究了从研究开始到结束期间,参与者的BMI水平以及肌钙蛋白水平。与保持正常体重的人相比,那些在第一次和第四次访问时都肥胖的人的肌钙蛋白水平增加到14纳克每升以上的可能性是其两倍,而在25岁时和第四次访问时都肥胖的人肌钙蛋白水平升高的可能性几乎是其四倍。

研究人员在0到50年的范围内列出每个人肥胖(定义为BMI超过30)的年数。即使考虑到高血压糖尿病和肾脏疾病导致的心脏疾病风险,对于每10年肥胖,其肌钙蛋白升高的风险就会增加1.25倍。

为了进行累计体重的测量,研究人员又计算了每位参与者的超重BMI-年数。使用25岁以及每次访问的数据,他们计算出平均BMI,并将平均超重BMI(超过25千克每平方米)乘以随访年数(从25岁到其在访问4时的年龄)。而在不同时间点BMI低于每平方米25千克的人,其超重BMI-年数为负值。

参与者的BMI-年的值为-274至1205。 平均而言,每100超重BMI-年数会导致21%的肌钙蛋白增加的可能性(或风险)。

“我们试图可以开发和测试如上面提到的超重BMI-年数指标来作为一种提醒年轻人和中年人,通过保持健康体重来减少长期心血管疾病风险的方法。”Ndumele表示。

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    2018-05-04 jyzxjiangqin

    肥胖越久.心脏越易受伤.

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    2018-04-23 jyzxjiangqin

    肥胖越久心脏越易受伤.

    0

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    2018-04-11 jyzxjiangqin

    肥胖越久.心脏越易受伤.

    0

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    2018-03-31 jyzxjiangqin

    肥胖症的治疗.

    0

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    2018-03-11 jyzxjiangqin

    肥胖影响心脏受伤害.

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    2018-02-27 杨利洪

    学习了分享一下

    0

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    2018-02-25 jyzxjiangqin

    胖为百病之源.

    0

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