Clinical Gastroenterology H:克罗恩病患者回肠切除术切除标本的显微病变与术后复发之间的关系

2019-12-27 不详 MedSci原创

有研究表明回肠边缘不同类型的组织学病变与克罗恩病(CD)患者回肠盲肠手术后复发率增加相关。本项研究旨在评估回肠边缘的组织学特征与疾病复发的关系。

背景和目标
有研究表明回肠边缘不同类型的组织学病变与克罗恩病(CD)患者回肠盲肠手术后复发率增加相关。本项研究旨在评估回肠边缘的组织学特征与疾病复发的关系。

方法
研究人员收集了2010年9月至2016年12月在法国医院接受回肠结肠切除术的211例回肠或回结肠CD患者的组织学数据,分析了标本回肠切缘病理特征。术后6个月,Rutgeerts评分等于或大于i2定义为早期内镜复发。同时研究人员还从接受回肠盲肠切除术治疗结肠肿瘤的10名健康回肠成人中收集了数据作为对照。临床复发的定义是通过影像学,内窥镜检查,治疗强度,CD相关并发症或后续手术证实。

结果
手术后六个月,有49%的患者发生了内镜复发。手术后5年,有57%的患者出现了临床复发。在13.6%的患者中观察到边缘的CD透壁病变(由粘膜溃疡或隐膜炎,粘膜下纤维化和浆膜下淋巴浆细胞浸润定义)。CD透壁病变的患者中有75%观察到内镜复发,而无CD透壁病变的患者中有46%出现内镜复发(P=.005)。在多变量分析中,边缘处的CD透壁病变与早期内镜复发(OR,3.83; 95%CI,1.47-11.05; P=.008 )和临床复发(OR 2.04; 95%CI,1.09-3.99; P = .026)密切相关。

结论
在CD患者中,回肠边缘的透壁病变与术后复发风险增加相关。

原始出处:

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createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 29 14:39:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
  5. 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createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 29 14:39:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2020-05-14 许安
  6. 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  7. 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