JACC:心梗过程中静脉注射他汀类药物可能明显减少心肌损伤

2020-03-26 MedSci原创 MedSci原创

除降脂外,他汀类药物还具有心脏保护作用。大剂量他汀类药物治疗似乎可以减少高危患者的心血管并发症。但是他汀类治疗理想的时机和管理体制仍然未知。本研究比较了心肌梗死(MI)时静脉注射他汀类药物与心肌梗死后

除降脂外,他汀类药物还具有心脏保护作用。大剂量他汀类药物治疗似乎可以减少高危患者的心血管并发症。但是他汀类治疗理想的时机和管理体制仍然未知。本研究比较了心肌梗死(MI)时静脉注射他汀类药物与心肌梗死后即刻口服他汀类药物的心脏保护作用。

本研究对高胆固醇血症猪进行了心梗诱导,并随访观察42天。本研究将动物分成3组,第一组动物在心肌梗死期间静脉注射阿托伐他汀,第二组动物在心肌梗死期间接受安慰剂静脉注射,第三组动物在心梗后2h接受口服阿托伐他汀治疗,第一和第三组患者在随访期间接受每日阿托伐他汀治疗。在心梗后3天,与第二和第三组相比,第一组动物的梗死面积减少10%,心梗后42天,与第二组相比,第一和第三组动物的疤痕面积均明显更小,然而,第一组动物的疤痕面积比第三组更小24%。功能分析显示,与第二组相比,第一组的收缩性能有所改善,受损心肌的室壁运动异常减少。另外,第一组与其他两组相比,瘢痕中胶原含量和AMP激活蛋白激酶活性增加,半影血管密度增加,肿瘤坏死因子α血浆水平升高,外周血单个核细胞活性降低。

研究结果显示,心梗过程中静脉注射他汀类药物可以明显减少心脏损伤,改善心功能。

原始出处:

Guiomar M et al.Intravenous Statin Administration During Myocardial Infarction Compared With Oral Post-Infarct Administration.JACC.2020 Mar.

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    2020-11-14 hbwxf
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    2020-05-18 fusion
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