Clin Gastroenterol H:非酒精性脂肪肝疾病患儿的孕妇和围产期危险因素

2021-04-18 MedSci原创 MedSci原创

孕妇孕前超重和肥胖与小儿NAFLD风险增加相关。当母乳喂养的时间足够长(≥6个月)时,母乳喂养可能会预防NAFLD的发生发展。

非酒精性脂肪性肝病(NAFLD)已成为最常见的小儿肝病类型。子宫内和早期生活环境可能对长期代谢健康产生重要影响。

近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员旨在明确孕前肥胖、(妊娠前)妊娠糖尿病、母乳喂养和出生人体测量学指标/早产对儿童和青少年NAFLD发生的影响。

研究人员检索了MEDLINE、PubMed Central、EMBASE和灰色文献库,检索时间截止至2020年8月。该研究的主要结局为小儿NAFLD患病率,而脂肪性肝炎和/或纤维化的组织学严重程度则是该研究的次要结局。由两名独立的审稿人进行研究选择,数据提取和质量评估。

该系统评价纳入了33篇文献。关于患者人群、诊断工具和整体质量的研究异质性相当可观。8项研究证实了孕妇孕前超重/肥胖的影响,并明确其为儿童NAFLD可能的可调整的危险因素。相反,有8项研究调查了(妊娠前)妊娠糖尿病的影响,但有关其效应的证据相互矛盾。母乳喂养与NAFLD、脂肪性肝炎和纤维化的风险降低相关,尤其是在评估母乳喂养时间较长的研究中尤为突出。早产或小胎龄对NAFLD的发生发展影响尚未明确,尽管早期追赶性生长可能会促进NAFLD的发生发展。

由此可见,孕妇孕前超重和肥胖与小儿NAFLD风险增加相关。当母乳喂养的时间足够长(≥6个月)时,母乳喂养可能会预防NAFLD的发生发展

原始出处:

Ilya Querter.et al.Maternal and perinatal risk factors for pediatric non-alcoholic fatty liver disease: A systematic review.Clinical gastroenterology and hepatology.2020.https://www.cghjournal.org/article/S1542-3565(21)00448-1/pdf

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    2021-08-24 许安
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