Radiology:左心室肥大是否会增加远期心血管不良事件发生的风险?

2020-01-04 shaosai MedSci原创

背景:目前,利用MRI左心室(LV)质量指标预测远期心血管(CV)不良事件发生风险的研究较少。本研究旨在评估在危险因子与冠状动脉钙化(CAC)评分的关系中LV质量升高对CV不良事件发生风险的影响。

背景:目前,利用MRI左心室(LV)质量指标预测远期心血管(CV)不良事件发生风险的研究较少。本研究旨在评估在危险因子与冠状动脉钙化(CAC)评分的关系中LV质量升高对CV不良事件发生风险的影响。

本研究共纳入了6814例基线时无临床CV疾病的患者。通过对4988例患者进行长达15年的CV不良事件随访中,利用半自动软件在心脏MRI图像中进行计算LV质量指标。利用COX比例危害模型、Kaplan-Meier曲线和z评分评价LV肥大的影响。

结果为,共有290例受试者出现冠心病(CHD)(207例患者为心肌梗死,95例患者因CHD死亡),57例患者发生CV相关性死亡,215例患者出现心脏衰竭(HF).LV肥大是预测严重CHD事件(HR: 2.7; 95%CI: 1.9, 3.8)、MI(HR: 2.8; 95% CI: 1.8, 4.0)、CHD死亡(HR: 4.3; 95% CI: 2.5, 7.3)、其他CV相关死亡(HR: 7.5; 95% CI: 4.2, 13.5)和HF (HR: 5.4; 95% CI: 3.8, 7.5)的独立指标。LV肥大是较CAC预测CHD、其他CV相关死亡和HF更强的指标(LV肥大vs CAC z评分: 5.4 vs 3.4, 6.8 vs 2.4, and 9.7 vs 3.2)。Kaplan-Meier分析显示在有LV肥大的患者中CV不良事件明显增高,尤其是在5年后。

本研究表明,在15年的随访中,左心室质量升高与严重冠心病不良事件、其他心血管相关性死亡和心脏衰竭具有显着相关性,独立于传统危险因子和冠状动脉钙化评分。

原始出处:

Kawel-Boehm N, Kronmal R, Eng J,et al.Left Ventricular Mass at MRI and Long-term Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis (MESA).Radiology.DOI:10.1148/radiol.2019182871

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