针对KRAS突变驱动的癌症疫苗

2019-08-08 Allan MedSci原创

免疫肿瘤学公司Elicio Therapeutics展示了针对7种KRAS突变(mKRAS)的靶向疫苗的重要临床前数据,KRAS突变驱动的癌症占所有人类实体瘤的25%。结果表明,靶向mKRAS-抗原能够实现强效细胞溶解。

免疫肿瘤学公司Elicio Therapeutics展示了针对7KRAS突变(mKRAS)的靶向疫苗的重要临床前数据,KRAS突变驱动的癌症占所有人类实体瘤的25%。结果表明,靶向mKRAS-抗原能够实现强效细胞溶解。

Elicio研究副总裁Peter DeMuth博士说:以前使用合成肽的疫苗方法不能有效地靶向驻留在淋巴结中的关键免疫细胞,在患者中仅引起微弱或不可检测的免疫反应。Amphiphile技术使我们能够同时对KRAS驱动的癌症中常见的七种突变产生免疫反应,方法是将具有强效佐剂的肽直接靶向淋巴结,显著放大所产生的免疫反应,并产生高功能的mKRAS特异性T细胞,能够在体内杀死mKRAS呈递细胞


原始出处:

http://www.firstwordpharma.com/node/1657631#axzz5w0bn7NRY

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    2019-08-10 yinhl1978
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    2019-08-10 bioon7
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    2019-08-08 329523732

    不错

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