JAMA Psychiatry:大麻会影响奖励机制

2016-07-22 Mechront 译 MedSci原创

最近的研究结果表明,年轻的成年人吸食大麻与奖励预期伏隔核神经反应的下降有关。密歇根大学的Mary Heitzeg博士对108名年轻的成年人进行了研究,探究使用大麻是否会影响奖励预期伏隔核的激活。研究者对参与者在20岁、22岁和24岁时进行了MRI扫描。收集参与者从11岁开始的大麻和其他药物的使用情况。研究表明,年轻的成年人吸食大麻与奖励预期伏隔核神经反应的下降有关(P = .01)。包括当前和先前

最近的研究结果表明,年轻的成年人吸食大麻与奖励预期伏隔核神经反应的下降有关。

密歇根大学的Mary Heitzeg博士对108名年轻的成年人进行了研究,探究使用大麻是否会影响奖励预期伏隔核的激活。研究者对参与者在20岁、22岁和24岁时进行了MRI扫描。收集参与者从11岁开始的大麻和其他药物的使用情况。

研究表明,年轻的成年人吸食大麻与奖励预期伏隔核神经反应的下降有关(P = .01)。包括当前和先前吸烟的交叉lagged模型分析表明,从22岁到24岁使用大麻对伏隔核神经反应的影响仍旧显著(P = .005),但是香烟对其的影响不明显。

研究者写道:“一些人可能认为大麻不会上瘾,或者相比其他成瘾药物,这是更好的选择,但这项研究提供的证据表明,使用大麻会影响大脑,让人难以停止使用它。”

原始出处:

Martz ME, et al. Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation.JAMA Psychiatry. 2016;doi:10.1001/jamapsychiatry.2016.1161.

Marijuana use may reduce neural response to reward anticipation
.Healio.July 21, 2016

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=112783, encodeId=ec3a112e8372, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 23:51:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792001, encodeId=7e7b1e92001c2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sun Feb 12 23:54:00 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272668, encodeId=85a912e26680e, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 24 11:54:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94393, encodeId=4bcc943931e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Jul 23 19:05:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94248, encodeId=90349424877, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:23:00 CST 2016, time=2016-07-23, status=1, ipAttribution=)]
    2016-09-06 李东泽

    很好,不错,以后会多学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=112783, encodeId=ec3a112e8372, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 23:51:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792001, encodeId=7e7b1e92001c2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sun Feb 12 23:54:00 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272668, encodeId=85a912e26680e, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 24 11:54:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94393, encodeId=4bcc943931e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Jul 23 19:05:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94248, encodeId=90349424877, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:23:00 CST 2016, time=2016-07-23, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=112783, encodeId=ec3a112e8372, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 23:51:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792001, encodeId=7e7b1e92001c2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sun Feb 12 23:54:00 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272668, encodeId=85a912e26680e, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 24 11:54:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94393, encodeId=4bcc943931e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Jul 23 19:05:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94248, encodeId=90349424877, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:23:00 CST 2016, time=2016-07-23, status=1, ipAttribution=)]
    2016-07-24 kcb069
  4. [GetPortalCommentsPageByObjectIdResponse(id=112783, encodeId=ec3a112e8372, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 23:51:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792001, encodeId=7e7b1e92001c2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sun Feb 12 23:54:00 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272668, encodeId=85a912e26680e, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 24 11:54:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94393, encodeId=4bcc943931e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Jul 23 19:05:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94248, encodeId=90349424877, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:23:00 CST 2016, time=2016-07-23, status=1, ipAttribution=)]
    2016-07-23 doctorJiangchao

    继续学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=112783, encodeId=ec3a112e8372, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 23:51:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792001, encodeId=7e7b1e92001c2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sun Feb 12 23:54:00 CST 2017, time=2017-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272668, encodeId=85a912e26680e, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Sun Jul 24 11:54:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94393, encodeId=4bcc943931e, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Jul 23 19:05:00 CST 2016, time=2016-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94248, encodeId=90349424877, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 23 11:23:00 CST 2016, time=2016-07-23, status=1, ipAttribution=)]
    2016-07-23 oo902

    好好学习

    0

相关资讯

家长们,块管管!孩子最可能11岁时尝试大麻!

大麻仍然是美国最常用的非法药物,它的使用在青少年中尤为普遍。现在,一项新的研究已经确定了青少年是最可能尝试药物的年龄,这可能会对目前的大麻干预计划有所意义。根据药物滥用研究所(NIDA),去年,大约6.5%八年级学生,14.8%对的10年级学生,以及21.3%的12年级被报道当前使用大麻。在12年级学生中,6%的学生每天使用大麻。大麻的使用可能会带来身体和心理健康上的一些风险,包括情绪变化,感觉改

重大突破!科学家发现大麻或有望治疗阿尔兹海默氏症

发表于国际杂志Aging and Mechanisms of Disease上的一项研究论文中,来自索尔克研究所的研究人员通过研究发现初步证据,即大麻中的四氢大麻酚(THC)和其它化合物可以促进β淀粉样蛋白从细胞中移除,β淀粉样蛋白是和阿尔兹海默氏症相关的一种毒性蛋白。尽管这项研究实在实验室生长的神经元中进行的,但其为开发治疗阿尔兹海默氏症的新型疗法提供了新的线索。 研究者David Schu

Human Brain Mapping:长期吸食大麻改变大脑奖赏回路

根据达拉斯得克萨斯大学的大脑健康中心研究人员称,长期吸食大麻会破坏大脑的自然奖励过程。 一篇发表在《Human Brain Mapping》杂志上的文章称,研究人员首次演示了功能性磁共振成像技术,研究表明长期吸食大麻会造成大脑皮层奖励系统中产生更多的活动。 “这项研究表明,大麻会扰乱大脑的自然反馈回路,尤其是大量吸食大麻的人问题更严重。从本质上说,这些大脑改变可能是由于轻度吸食大麻到重度吸食

JAMA Psychiatry:不良牙周健康与大麻的使用有关

最近的研究结果表明,大麻的使用与中年早期不良的牙周健康相关,但不与其他健康问题有关。 亚利桑那州国家大学的Madeline H. Meier博士对1037名1972-1973年出生在新西兰的参与者进行了随访38年的研究,随访率95%,探究大麻的使用和中年早期健康问题之间的关联。分别在参与者18、21、26、32和38岁时评估了大麻使用和依赖情况。 通过每日吸烟量确定累积烟草暴露情况,“

Health Affair:医用大麻合法化降低了处方药的使用

发表在Health Affairs的研究称,在美国的一些州医用大麻合法化减少了处方药的使用,相当于2013年节省了超过1亿6500万美元。截至上个月,美国共有25个州和华盛顿特区针对某些健康问题(如神经性疼痛和痉挛)对大麻合法化。在2013年时,美国有17个会州和华盛顿特区合法化医用大麻。美国食品和药物管理局(FDA)并没有急于科学证据批准大麻,目前还不知道大麻的有效性和安全性。大麻的合法化是基于