J Pediatr Hematol Oncol:小儿肿瘤患者侵袭性真菌感染的诊断方法

2020-10-04 MedSci原创 MedSci原创

小儿肿瘤患者肺部侵袭性真菌感染(IFI)的诊断具有挑战性。2008年制定的共识标准指出,支气管肺泡灌洗(BAL)结果不能确诊。视频辅助胸腔镜肺活检(VATS-biopsy)已被越来越多地用于协助评估这

小儿肿瘤患者肺部侵袭性真菌感染(IFI)的诊断具有挑战性。2008年制定的共识标准指出,支气管肺泡灌洗(BAL)结果不能确诊。视频辅助胸腔镜肺活检(VATS-biopsy)已被越来越多地用于协助评估这些儿童的IFI。本项回顾性分析旨在评估BAL和VATS-biopsy结果对儿童肿瘤患者IFI管理的影响,研究结果已在线发表于J Pediatr Hematol Oncol。

研究纳入在一家独立的儿童医院对9年内所有接受VATS-活检和/或BAL评估IFI的肿瘤患者。主要结果是根据诊断程序、真菌培养结果、肺部影像学和血清学标志物使用抗真菌治疗的管理变化。

 

结果,共有102名患者接受了122次IFI的诊断评估。91例工作评价仅包括BAL,17例评价仅涉及VATS-biopsy,14例同时包括BAL和VATS-biopsy。VATS-biopsy的诊断率(38.7%)优于BAL(27.6%)。在14例同时进行VATS-活检和BAL检查的病例中,两者的结果一致性较差。工作检查完成后,12例患儿被证实为IFI,29例很可能,52例可能。很可能的IFI患者继续抗真菌治疗的几率增加了3倍,已证实的患者增加了12.7倍。

 

综上所述,该研究结果表明,在BAL诊断率较低的基础上,VATS-biopsy可能是免疫功能低下的儿童肿瘤患者群体中IFI诊断中更有用的诊断辅助手段。

 

原始出处:

 

Erica I HodgmanJeffrey Compton, et al., Diagnosis of Invasive Fungal Infection Among Pediatric Oncology Patients. J Pediatr Hematol Oncol. 2019 Nov;41(8):596-600. doi: 10.1097/MPH.0000000000001516.

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encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Mar 26 20:00:23 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317594, encodeId=a019131e594d1, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353805, encodeId=879d13538052e, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360351, encodeId=58251360351ed, content=<a href='/topic/show?id=ec0fe2676d0' target=_blank style='color:#2F92EE;'>#真菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72676, encryptionId=ec0fe2676d0, topicName=真菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366376, encodeId=b47b13663e63f, content=<a href='/topic/show?id=186126998e2' target=_blank style='color:#2F92EE;'>#侵袭性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26998, encryptionId=186126998e2, topicName=侵袭性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424326, encodeId=1b6014243261a, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038125, encodeId=54d310381255b, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Oct 04 19:00:23 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2021-03-26 minlingfeng
  5. [GetPortalCommentsPageByObjectIdResponse(id=1728681, encodeId=19f51e2868168, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Apr 14 14:00:23 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639623, encodeId=7c6c1639623f0, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Aug 22 06:00:23 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709888, encodeId=53771e09888fb, content=<a href='/topic/show?id=2b01916235e' target=_blank style='color:#2F92EE;'>#诊断方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91623, encryptionId=2b01916235e, topicName=诊断方法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=977d31798651, createdName=haouestc, createdTime=Mon Nov 16 12:00:23 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865923, encodeId=b17b186592350, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, 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level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360351, encodeId=58251360351ed, content=<a href='/topic/show?id=ec0fe2676d0' target=_blank style='color:#2F92EE;'>#真菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72676, encryptionId=ec0fe2676d0, topicName=真菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366376, encodeId=b47b13663e63f, content=<a href='/topic/show?id=186126998e2' target=_blank style='color:#2F92EE;'>#侵袭性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26998, encryptionId=186126998e2, topicName=侵袭性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424326, encodeId=1b6014243261a, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038125, encodeId=54d310381255b, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Oct 04 19:00:23 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-06 智智灵药
  6. 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createdName=智者为医08, createdTime=Sun Aug 22 06:00:23 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709888, encodeId=53771e09888fb, content=<a href='/topic/show?id=2b01916235e' target=_blank style='color:#2F92EE;'>#诊断方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91623, encryptionId=2b01916235e, topicName=诊断方法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=977d31798651, createdName=haouestc, createdTime=Mon Nov 16 12:00:23 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865923, encodeId=b17b186592350, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Mar 26 20:00:23 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317594, encodeId=a019131e594d1, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353805, encodeId=879d13538052e, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360351, encodeId=58251360351ed, content=<a href='/topic/show?id=ec0fe2676d0' target=_blank style='color:#2F92EE;'>#真菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72676, encryptionId=ec0fe2676d0, topicName=真菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366376, encodeId=b47b13663e63f, content=<a href='/topic/show?id=186126998e2' target=_blank style='color:#2F92EE;'>#侵袭性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26998, encryptionId=186126998e2, topicName=侵袭性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424326, encodeId=1b6014243261a, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Tue Oct 06 07:00:23 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038125, encodeId=54d310381255b, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Oct 04 19:00:23 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-06 zhaojie88
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038125, encodeId=54d310381255b, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Oct 04 19:00:23 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038125, encodeId=54d310381255b, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Oct 04 19:00:23 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-06 sunyl07
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038125, encodeId=54d310381255b, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Oct 04 19:00:23 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-04 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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