Int J Oral Max Surg:口腔鳞状细胞癌患者唾液和血浆中细胞因子生物标志物

2018-04-22 MedSci MedSci原创

这项研究的目的是调查人类唾液和血浆中潜在的生物标志物,以帮助早期诊断口腔鳞状细胞癌(OSCC)。

这项研究的目的是调查人类唾液和血浆中潜在的生物标志物,以帮助早期诊断口腔鳞状细胞癌(OSCC)。

获取OSCC患者(n = 41)和非口腔癌患者(n = 24)的唾液和血浆样本,并用Luminex Bead-based Multiplex Assay分析。使用非参数Mann-Whitney U检验,Kruskal-Wallis检验和受试者工作特征曲线(ROC)分析数据,以评估单独用于OSCC诊断的14种生物标志物的预测能力。早期OSCC中IP-10的血浆水平与对照组差异显着。唾液生物标志物中IL-1β,IL-6,IL-8,MIP-1β,eotaxin和IFN-γ和TNF-α在OSCC患者和对照组间均有显着性差异。关于致癌作用,OSCC III / IV期和OSCC I / II期间血浆eotaxin,G-CSF和IL-6水平存在显着差异。对于OSCC与对照的曲线下面积(AUC),对于血浆IP-10和唾液IL-1β,IL-6,IL-8和TNF-α大于0.7。研究结果表明,唾液生物标志物可以作为早期检测口腔OSCC的补充辅助手段。关于肿瘤进展的评估,血浆eotaxin,G-CSF和IL-6可能有助于检测晚期OSCC。然而,OSCC中唾液和血浆生物标志物之间的相关性较弱。

原始出处:

L.T. Lee, et al. Evaluation of saliva and plasma cytokine biomarkers in patients with oral squamous cell carcinoma. Internatonal Journal of Oral and Maxillofacial Surgery. 2018 June. doi:10.1016/j.ijom.2017.09.016

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    2019-02-23 小几洁
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    2018-05-05 沙漠浪人

    口腔癌检测

    0

  6. 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  7. 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