J Med Life：1型糖尿病合并抑郁者转归较差

　　抑郁是临床上最常见的精神疾病之一。多项研究显示抑郁症状可预测不同并发症（如心脏病、糖尿病、卒中及其他疾病）的发生，尽管如此，抑郁与糖尿病的关系仍未可知。

　　罗马尼亚布加勒斯特临床抑郁精神科Ladea M等人进行了一项研究，对严重抑郁障碍（MDD）合并1型或2型糖尿病患者进行评估，观察足量治疗时患者抑郁与糖尿病症状的改变。

　　研究入选43例患者，患者经诊断有MDD与1型或2型糖尿病。所有患者接受抗抑郁与抗糖尿病治疗。患者平均年龄49.7岁，其中60.5%患者为女性，平均住院时间为23日。

　　结果显示合并1型糖尿病的患者住院时间普遍较长，抑郁症状更重。伴随病情好转患者出院时血糖水平亦有所下降。

　　由此研究者认为，合并1型糖尿病的抑郁患者病情更重，需要更高剂量抗抑郁药，住院时间也更长。抑郁症状的改善似乎对患者血糖改善有正向影响。 

与糖尿病相关的拓展阅读：

• 精神健康状况可作为糖尿病自我监护指标
• 1型糖尿病合并抑郁者转归较差
• MedPage：加拿大新指南称糖尿病患者40岁时应该使用他汀类药物
• Diabetes Care：维生素D缺乏不能预测糖尿病患者心血管风险 更多信息请点击：有关糖尿病更多资讯

Metabolic imbalance in affective disorders.
Introduction
Depression is the most frequent mental disorder encountered in all medical services. Multiple studies have shown that depression may predict the onset of different conditions, such as heart disease, diabetes, stroke and many other. The relation between depression and diabetes is still unclear.
Materials and methods
In this study we evaluated patients with both major depressive disorder and type 1 or 2 diabetes, and observed the evolution of depressive and diabetes symptoms under adequate treatment. This observational, naturalistic study included 43 patients admitted in a psychiatric ward of "Alexandru Obregia" Clinical Hospital, Bucharest, diagnosed with Major Depressive Disorder (MDD) and Diabetes mellitus (DM) type 1 or 2. All patients received antidepressant and antidiabetic treatment.
Results
The majority of patients were women (60.5%), and the mean age was 49.7 years. Average hospitalization period was 23 days, with longer period of hospitalization of patients with DM type 1. Patients had severe depression. Mean value of fasting glycemia at admission was of 174 mg / dl, but it decreased at discharge, in paralel with the amelioration of depression.
Conclusions
The depression associated with DM type 1 is more severe. These patients require higher doses of antidepressants and longer hospitalization period. Amelioration of depression seems to have a positive impact on the blood sugar level of depressed patients with diabetes.