J Thromb Haemost:抗磷脂抗体阳性的静脉或动脉血栓栓塞患者复发性血栓形成

2020-06-04 MedSci原创 MedSci原创

与aPL阳性的VTE患者相比,aPL阳性的ATE患者可能受益于不同的抗栓方法。为了确定最佳的抗血栓形成策略,必须对具有明确定义的aPL阳性的TE队列进行前瞻性研究。

抗磷脂抗体(aPL)阳性和血栓栓塞(TE)患者有TE复发的风险。但是,很少有研究能够根据初始事件区分患者。

近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员进行了系统回顾和荟萃分析以调查诱发或未诱发的aPL阳性的静脉TE(VTE)患者以及动脉TE(ATE)患者。研究人员在PubMed、CINAHL,Cochrane和EMBASE数据库中进行了检索。入选标准为前瞻性试验或队列研究,参与者为aPL阳性的ATE患者或VTE患者。排除未提供估计的复发率、未指定事件是ATE还是VTE、包括多个事件的患者、或<10个患者的研究。研究人员使用随机效应模型估算两年汇总比例。

十项研究描述了VTE患者,2项描述了ATE患者,5项描述了VTE或ATE患者。在接受抗凝治疗的VTE患者中,TE的两年复发率为0.054(95%置信区间[CI]:0.037,0.079);未接受抗凝治疗的患者的两年比例为0.178(95%CI:0.150,0.209)。大多数研究没有区分是诱发或未诱发的VTE。在接受抗凝治疗的ATE患者中两年内TE复发的比例为0.220(95%CI:0.149,0.311);接受抗血小板治疗的患者两年复发比例为0.216(95%CI:0.177,0.261)。

与aPL阳性的VTE患者相比,aPL阳性的ATE患者可能受益于不同的抗栓方法。为了确定最佳的抗血栓形成策略,必须对具有明确定义的aPL阳性的TE队列进行前瞻性研究。

原始出处:

Thomas L. Ortel.et al.Recurrent Thrombosis in Patients with Antiphospholipid Antibodies and an Initial Venous or Arterial Thromboembolic Event: A Systematic Review and Meta‐Analysis.Journal of Thrombosis and Haemostasis.2020.https://doi.org/10.1111/jth.14936

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    2020-07-12 changfy
  2. [GetPortalCommentsPageByObjectIdResponse(id=2008473, encodeId=452f20084e33d, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sun Jul 12 20:14:27 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961127, encodeId=605196112edc, content=对临床有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0c3b2403675, createdName=1235de60m66(暂无昵称), createdTime=Wed Apr 28 09:09:11 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698105, encodeId=03de16981057a, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Mon Dec 07 21:14:27 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709017, encodeId=feea1e090176f, content=<a href='/topic/show?id=1502333250f' target=_blank style='color:#2F92EE;'>#动脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33325, encryptionId=1502333250f, topicName=动脉血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=048f31575940, createdName=ms9833124466084992, createdTime=Fri Sep 11 06:14:27 CST 2020, time=2020-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948125, encodeId=1868194812572, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Sep 21 06:14:27 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722155, encodeId=11db1e2215530, content=<a href='/topic/show?id=3d955558116' target=_blank style='color:#2F92EE;'>#抗磷脂抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55581, encryptionId=3d955558116, topicName=抗磷脂抗体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e5833182948, createdName=whmdzju, createdTime=Sat Apr 17 19:14:27 CST 2021, time=2021-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909821, encodeId=7144190982123, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Jan 31 13:14:27 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601675, encodeId=06036016e5b9, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Jun 06 22:24:44 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536827, encodeId=4ff8153682e85, content=<a href='/topic/show?id=fcbd3332949' target=_blank style='color:#2F92EE;'>#动脉血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33329, encryptionId=fcbd3332949, topicName=动脉血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=715e12724163, createdName=yangcx0919, createdTime=Sat Jun 06 12:14:27 CST 2020, time=2020-06-06, status=1, ipAttribution=)]
    2021-04-28 1235de60m66(暂无昵称)

    对临床有意义

    0

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    2020-12-07 fusion
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    2021-01-31 hb2008ye
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    2020-06-06 wxl882001

    了解

    0

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