Cancer：血管内皮生长因子治疗转移性甲状腺癌的效果

2020-07-13 MedSci原创 MedSci原创

一些多靶点酪氨酸激酶抑制剂(TKIs)在对放射性碘(RAI)耐药的甲状腺癌患者中显示出抗肿瘤活性，部分归因于这些TKIs能够抑制这些血管肿瘤的血管生成。血管内皮生长因子(VEGF)陷阱(VT)是一种重

一些多靶点酪氨酸激酶抑制剂(TKIs)在对放射性碘(RAI)耐药的甲状腺癌患者中显示出抗肿瘤活性，部分归因于这些TKIs能够抑制这些血管肿瘤的血管生成。血管内皮生长因子(VEGF)陷阱(VT)是一种重组生产的融合蛋白，完全由VEGF受体1和2胞外域的人序列和人免疫球蛋白1组成。考虑到靶向VEGF的TKIs观察到的活性，因此，有必要在甲状腺癌患者中评估VT。

本研究是一项单机构、2期、Simon 2阶段设计（21至>41名患者）的研究，基于客观反应率和/或6个月无进展生存期作为主要终点。符合条件的患者需要有进展性、RAI难治性和/或[18 F]氟脱氧葡糖苷不耐受、复发和/或转移性、非髓质、非肿瘤性甲状腺癌；使用实体瘤中反应评价标准（RECIST）标准可测量的疾病；以及足够的器官和骨髓功能。每14天静脉注射4mg/kg剂量的VT。

结果，共有40名患者被纳入分析。其中24名患者为甲状腺乳头状癌，2名患者为甲状腺滤泡癌，11名患者为Hurthle细胞甲状腺癌。最后3个肿瘤被归类为分化不良。没有注意到完全和/或部分反应；34名患者获得了稳定的疾病，6名患者的最佳反应是疾病进展。在34名疾病稳定的患者中，16名患者仍在研究中超过6个月，6名患者仍在研究中超过12个月。治疗的中位时间为4.1个月（范围，0.6-30.8个月）。

综上所述，该研究结果表明，与TKIs不同的是，TKIs在这种情况下已经显示出反应，据作者所知，迄今为止还没有观察到使用单药VT的反应。它似乎不是治疗甲状腺癌患者的有前途的药物。

原始出处：

Eric J Sherman, Lara A Dunn,et al., Phase 2 Study of Vascular Endothelial Growth Factor Trap for the Treatment of Metastatic Thyroid Cancer. Cancer. 2019 Sep 1;125(17):2984-2990. doi: 10.1002/cncr.32046.

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2020-07-15 1249842em09(暂无昵称)

#转移性#

38 0
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2020-07-15 12499e01m50暂无昵称

#生长因子#

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2020-07-15 qilu_qi

#血管内皮生长因子#

47 0
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2020-07-13 lovetcm

#甲状腺癌#抗血管新生治疗应该🈶️效。安罗替尼，贝伐等

196 0
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2020-07-13 lovetcm

#甲状腺乳头癌#最近几年，越来越重视甲状腺癌的诊断和治疗

91 0
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2020-07-13 CHANGE

疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

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Cancer：血管内皮生长因子治疗转移性甲状腺癌的效果