Stroke:HDL亚型与隐性脑梗塞和缺血性卒中事件的关系

2021-10-15 MedSci原创 MedSci原创

高密度脂蛋白(HDL)是否与血管性脑损伤的风险相关尚未明确。HDL由许多种载脂蛋白组成,形成了不同的HDL亚型。

高密度脂蛋白(HDL)是否与血管性脑损伤的风险相关尚未明确。HDL由许多种载脂蛋白组成,形成了不同的HDL亚型。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员利用夹心法ELISA来测定在1998/1999年期间收集的来自于2001年CHS(心血管健康研究)参与者(平均年龄为80岁)血浆中的HDL亚种。

在横断面分析中,血浆中较高apoA1和HDL中较低apoE水平的参与者不太可能发生隐蔽性磁共振成像确定的梗塞:apoA1水平Q4与Q1的比值比为0.68(95%CI为0.50-0.93),apoE水平Q4与Q1的比值比为1.36(95%CI为1.01-1.84)。同样,在前瞻性分析中,缺乏apoC3、apoJ或apoE的HDL亚型中apoA1水平与隐性梗塞呈负相关,缺乏apoC3或apoJ的HDL亚型中apoE水平与隐性梗塞直接相关。

相比之下,包含这些apos的HDL互补亚型中的apoA1和apoE浓度与隐性梗塞无关。临床显著的缺血性卒中与HDL亚型中的apoA1、apoE和apoA1和apoE之间的关联模式与隐性梗塞观察到的相似,但不那么显著。

由此可见,这项研究强调了由载脂蛋白含量确定的HDL亚种,可作为隐性和显性血管脑损伤的相关生物标志物。

原始出处:

Manja Koch.et al.HDL (High-Density Lipoprotein) Subspecies, Prevalent Covert Brain Infarcts, and Incident Overt Ischemic Stroke: Cardiovascular Health Study.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.034299

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    2021-10-17 ZGMFX24A
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    2021-10-17 karmond

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