JACC:妊高症妇女远期的心血管疾病风险明显增加

2019-11-26 不详 MedSci原创

女性妊娠高血压疾病(HDP)史可能有助于改善动脉粥样硬化性心血管疾病的风险评估。然而,有HDP病史的无症状中年妇女心血管疾病的未来风险仍然未知。本研究的目的旨在比较和评估有HDP史和无HDP史妇女的远期不良心血管疾病发生率。本研究纳入分析了英国生物数据库中的220024名年龄在40-69岁之间至少有过1次生产史的妇女,其中有2808名(1.3%)有过HDP病史,基线的平均年龄为57.4±7.8岁,

女性妊娠高血压疾病(HDP)史可能有助于改善动脉粥样硬化性心血管疾病的风险评估。然而,有HDP病史的无症状中年妇女心血管疾病的未来风险仍然未知。本研究的目的旨在比较和评估有HDP史和无HDP史妇女的远期不良心血管疾病发生率。


本研究纳入分析了英国生物数据库中的220024名年龄在40-69岁之间至少有过1次生产史的妇女,其中有2808名(1.3%)有过HDP病史,基线的平均年龄为57.4±7.8岁,经过平均7年时间的随访,与无HDP病史的妇女相比,有HDP病史的妇女的动脉僵硬指数更高,慢性高血压的风险也更高。总的来说,有HDP病史和无HDP病史妇女的心血管疾病发生率分别是7.0/1000人年和5.3/1000人年(p = 0.001)。另外,HDP与更高的心衰、主动脉狭窄和二尖瓣反流的发生率相关。


研究结果显示,妊娠高血压病与加速的心血管老化和更多样的心血管疾病发生有关,HDP后的心血管风险主要但不完全由慢性高血压的发展介导。


原始出处:

Michael C et al.Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy.JACC.2019 Nov.


本文系梅斯医学(MedSci)原创编译整理,转载需授权


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    2020-08-07 hbwxf
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    2020-05-10 zxxiang
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    2019-11-26 一个字-牛

    学习了谢谢分享

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