JAMA Netw Open:老年人听力和视觉障碍竟会增加痴呆症风险?

2022-05-14 医路坦克 MedSci原创

听力和视力问题分别与痴呆风险增加有关,本研究证实双重感觉障碍(DSI)与痴呆症,特别是阿尔茨海默病(AD)的风险增加有关,评估老年人的听力和视力可能有助于识别那些患痴呆症的高危人群。

听力和视力问题分别与痴呆风险增加有关,但同时存在听力和视力缺陷,即双重感觉障碍(DSI)对痴呆风险的影响尚不清楚,包括其主要亚型阿尔茨海默病(AD)和血管性痴呆(VAD)。

这项来自心血管健康研究(CHS)的前瞻性队列研究是在1992至1999年间进行的,并进行了长达8年的随访。这一多中心、基于人群的样本是从美国4个拥有学术医疗中心的社区的医疗保险资格文件中招募的。在CHS的5888名年龄在65岁及以上的参与者中,3602人接受了头颅磁共振成像,并在1992至1994年间完成了修订的简易智力状态检查,作为CHS认知研究的一部分。共有227名参与者因普遍存在的痴呆症而被排除在外,在研究基线时,总共有3375名参与者没有痴呆症。

研究假设是,与没有感觉障碍相比,DSI与痴呆症风险增加有关。还评估了DSI持续时间与痴呆症风险之间的关系。数据分析时间为2019年11月至2020年2月。

共有2927名参与者在所有可用的研究访问中获得了关于听力和视觉的信息(平均年龄[SD],74.6[4.8]岁;1704[58.2%]女性;455[15.5%]非裔美国人或黑人;2472[85.5%]白人)。与无感觉损害相比,DSI与全因痴呆(危险比,2.60;95%CI,1.66-2.06;P<.001)、AD(HR,3.67;95%CI,2.04-6.60;P<.001)的风险增加有关,但与VaD(HR,2.03;95%CI,1.00-4.09;P=.05)无关。

在这项队列研究中,DSI与痴呆症,特别是AD的风险增加有关。评估老年人的听力和视力可能有助于识别那些患痴呆症的高危人群。

文献来源:Hwang PH,  Longstreth WT,  Thielke SM,Longitudinal Changes in Hearing and Visual Impairments and Risk of Dementia in Older Adults in the United States.JAMA Netw Open 2022 May 02;5(5)

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    2023-04-27 feather89
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    2023-02-09 canlab
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    2022-12-18 Boyinsh
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    2022-05-14 ysjykql
  6. [GetPortalCommentsPageByObjectIdResponse(id=1729553, encodeId=1d491e29553e5, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Apr 27 19:52:52 CST 2023, time=2023-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734504, encodeId=0ed51e34504e6, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Thu Feb 09 22:52:52 CST 2023, time=2023-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836306, encodeId=921a18363062f, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Dec 18 06:52:52 CST 2022, time=2022-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661286, encodeId=3c7b166128632, content=<a href='/topic/show?id=39c79088173' target=_blank style='color:#2F92EE;'>#视觉障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90881, encryptionId=39c79088173, topicName=视觉障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a4c25257079, createdName=12498484m54(暂无昵称), createdTime=Wed Nov 02 11:52:52 CST 2022, time=2022-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306728, encodeId=328f1306e28d5, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Sat May 14 13:52:52 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481153, encodeId=9a7f1481153ee, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Sat May 14 13:52:52 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243503, encodeId=295912435033b, content=JAMA上文章都是顶级的,谢谢梅斯及时上新, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri May 13 01:52:52 CST 2022, time=2022-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247100, encodeId=2ccc124e10010, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Fri May 13 01:52:52 CST 2022, time=2022-05-13, status=1, ipAttribution=)]
    2022-05-14 zywlvao
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    2022-05-13 肿瘤克星

    JAMA上文章都是顶级的,谢谢梅斯及时上新

    0

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    2022-05-13 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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