NEJM:马拉维儿童伤寒结合疫苗的安全性和效果

2021-09-16 MedSci原创 MedSci原创

在9个月至12岁的马拉维儿童中,与MenA疫苗相比,接种Vi-TCV疫苗可降低经血培养证实的伤寒发生率。

由多重耐药H58伤寒沙门氏菌引起的伤寒是撒哈拉以南非洲地区日益严重的公共卫生威胁。


近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员在马拉维布兰太尔进行了一项3期双盲试验,以评估Vi多糖伤寒结合疫苗(Vi-TCV)的功效。

研究人员以1:1的比例将9个月至12岁的儿童随机分配到接种单剂Vi-TCV或脑膜炎球菌A群结合物(MenA)疫苗接种。该研究的主要结局是经血培养证实的伤寒。研究人员在18至24个月的随访后报告了疫苗有效性和安全性结局。


该意向治疗分析纳入了28130名儿童,其中14069名儿童被分配接种Vi-TCV,14061名儿童被分配接种MenA疫苗。Vi-TCV组12名儿童(每10万人每年46.9例)和MenA组62名儿童(每10万人每年243.2例)发生了经血培养证实的伤寒。总体而言,接种Vi-TCV的疗效在意向治疗分析中为80.7%(95%置信区间[CI]为64.2至89.6),在符合方案分析中为83.7%(95%CI为68.1至91.6)。在疫苗接种后的前6个月内,总共发生了130起严重不良事件(Vi-TCV组52起,MenA组78起),其中6起死亡病例(均发生在MenA组)。研究人员认为没有严重的不良事件与疫苗接种相关。
 
由此可见,在9个月至12岁的马拉维儿童中,与MenA疫苗相比,接种Vi-TCV疫苗可降低经血培养证实的伤寒发生率。

原始出处:
 
Priyanka D. Patel,et al.Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children.NEJM.2021.https://www.nejm.org/doi/full/10.1056/NEJMoa2035916

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    2021-09-17 查查佳佳

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    2021-09-16 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1052221, encodeId=a2fb105222194, content=担心咯额我靠贼婆闭区间谍同盟里, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 17 08:41:41 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052721, encodeId=a4c31052e217e, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Sep 16 17:33:49 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052030, encodeId=dfed105203026, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210916/57b3c5647516472bbdfec845de125677/72dd5ac8770449449f718198246d2427.jpg, createdBy=dfa75608180, createdName=ms6000001733897940, createdTime=Thu Sep 16 16:30:55 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052022, encodeId=ce751052022ad, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Thu Sep 16 16:08:51 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052021, encodeId=1f881052021a2, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210817/43a1d57f79934b84a056879057182725/76af758a9a5f4b4cbf97fff2aae3cb15.jpg, createdBy=e03e5535659, createdName=夕火, createdTime=Thu Sep 16 16:06:18 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2021-09-16 ms6000001733897940

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    2021-09-16 yangchou

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    2021-09-16 夕火

    学习学习

    0

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