CHEST:肥胖低通气综合征患者在术前识别高碳酸血症十分有必要

2016-01-09 fsy 译 MedSci原创

在OSA患者中,与单纯患有OSA患者相比,较多的医疗合并症被认为是与患有肥胖低通气综合征(OHS)相关的。OHS可能会造成择期非心脏手术(NCS)后的术后并发症的风险较高,通常是未知的手术时间。本研究的目的是回顾性识别OHS患者,并与那些只患有OSA的患者比较了他们的手术后的结果。符合OHS标准的患者被确定在一个大型队列中,这些OSA患者在一家大型三级医疗中心接受了择期NCS。研究人员确定了与OS

在阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者中,与单纯患有OSA患者相比,较多的医疗合并症被认为是与患有肥胖低通气综合征(OHS)相关的。OHS可能会造成择期非心脏手术(NCS)后的术后并发症的风险较高,通常是未知的手术时间。本研究的目的是回顾性识别OHS患者,并与那些只患有OSA的患者比较了他们的手术后的结果。

符合OHS标准的患者在一个大型队列中被确定,这些OSA患者在一家大型三级医疗中心接受了择期NCS。研究人员确定了与OSA和OHS相关的术后结果作为临床决定因素(BMI,呼吸暂停低通气指数[AHI])。多变量逻辑和线性回归模型被分别用于分析二分法和连续的结果。

与OSA患者相比,确诊或可能的OHS和重叠综合征高碳酸血症患者更有可能经历术后呼吸衰竭(OR,10.9;95%Cl,3.7-32.3;P<0.0001),术后心脏衰竭(OR,5.4;95%Cl,1.9-15.7;P=0.002),长时间插管(OR,3.1;95%Cl,0.6-15.3;P=0.2),术后ICU转移(OR,10.9;95%Cl,3.7-32.3;P<0.0001),和更长的ICU(β系数为0.86;SE,0.32;P=0.009)和住院时间(β系数,2.94;SE,0.87;P=0.0008)。通过单变量和多变量回归,在OHS的临床决定因素中,无论是BMI还是AHI都不与任何术后结果相关。

阻塞性睡眠呼吸暂停或重叠综合征接受择期NCS患者术前识别高碳酸血症,是非常有必要的。

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    2016-08-12 Smile2680
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