达匹韦林阴道环,预防艾滋病的新选择

2021-01-28 Allan MedSci原创

世卫组织(WHO)今天建议,作为联合预防方法的一部分,可以将达匹韦林阴道环(DPV-VR)作为具有重大感染风险的患者的预防策略。

世卫组织(WHO)今天建议,作为联合预防方法的一部分,可以将达匹韦林阴道环(DPV-VR)作为具有重大感染风险的患者的预防策略。

DPV-VR可以减少感染HIV的风险。为了正确使用阴道环,必须将其在阴道内佩戴28天,然后再换上新的阴道环。阴道环由硅树脂制成,易于弯曲和插入。该环通过在28天之内将抗逆转录病毒药物达匹韦林(dapivirine)从阴道环中缓慢释放到阴道中而起作用。

两项III期随机对照试验发现,使用DPV-VR可以降低女性感染HIV的风险,长期耐受性良好。使用DPV-VR可使女性感染HIV的风险降低27%-35%。开放标签延伸研究的结果表明,始终使用DPV-VR的女性的HIV风险降低率则更高。

DPV-VR可以与口服PrEP(暴露前预防)一起使用,作为不希望或无法每天服用口服片剂的女性的选择。尽管避孕环已问世了数年,但DPV-VR是第一个预防HIV的产品。

 

原始出处:

https://www.firstwordpharma.com/node/1795306?tsid=4

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    2021-12-31 ms9000000107532796

    学习

    0

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    2021-11-16 ms1000001994227128

    上帝的病毒

    0

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    2021-01-29 Jason20042008

    希望早日战胜此疾病!

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