EHJ:昨晚睡得如何?40万人数据提示睡眠时长与常见心血管疾病的关系

2021-04-18 MedSci原创 MedSci原创

正常的睡眠结构周期分两个时相:非快速眼动睡眠(NREM)和快速眼动睡眠(REM)。

正常的睡眠结构周期分两个时相:非快速眼动睡眠(NREM)和快速眼动睡眠(REM)。NREM与REM交替出现,交替一次称为一个睡眠周期,两种时相循环往复,每夜通常有 4~5个睡眠周期,每个周期90~110分钟。

英国《每日邮报》曾有文章称,通过研究发现,与每晚睡眠超过7小时或不足7小时的老年人相比,每晚睡眠限制在7小时的老人其大脑衰老可推迟两年。其实,睡觉时长影响健康的研究已经很多,但是结论都不是十分一致。目前大家普遍接受的观点是,睡眠太长太短一样都不利于健康。那么究竟睡多长时间更健康呢?

人类不同年龄的睡眠时间是不同的,婴儿的睡眠时间为18-20小时,幼儿需要9~12小时,学童需要9~10小时,成人需要7~9小时,老年人需要6~8小时,大于80岁的老年人需要9~10小时。

观察性研究表明,睡眠时间与许多血管疾病(CVDs)之间有很强的关联,但因果推断尚未得到证实。为此,来自香港中文大学的心血管领域专家旨在利用线性和非线性孟德尔随机化(MR)设计,确定基因预测的睡眠时间与12种CVDs之间的因果关系。结果发表在最新的《欧洲心脏病学》EHJ杂志上。

研究人员利用了连续短(≤6 h)和长(≥9 h)睡眠持续时间相关的遗传位点,在404044名英国生物库(UK Biobank)的英国参与者中考察了与12种CVDs的因果关系。

线性MR分析显示,在校正多重检验后,如果参与者存在预测睡眠时间长的单核苷酸多态性(SNP)位点,那么基因预测的睡眠时间与动脉高血压、房颤、肺栓塞和慢性缺血性心脏病呈负相关。即,每多睡1小时,上述疾病发病率反而下降。

非线性MR分析表明,如果参与者存在短睡相关SNP位点,则基因预测的睡眠时间与四种CVD之间存在非线性(L型关联)相关,分别是动脉高血压、慢性缺血性心脏病、冠状动脉疾病和心肌梗死

进一步的补充分析提供了确凿证据,证明基因预测的短睡眠对12种CVD中的5种CVD的风险有不利影响,包括动脉高血压、肺栓塞、冠状动脉疾病、心肌梗死和慢性缺血性心脏病。然而,基因预测的长睡眠时间与任何CVDs无关。

睡眠时间长短与12种心血管疾病的因果关系:英国生物库的线性和非线性孟德尔随机分析。

既往的研究都认为,睡眠与CVDs风险,或者全因死亡风险之间的关系,是一种“U型”或者“J型”曲线:一般认为7-8小时的睡眠最佳,与之相比,不足6小时或超过9小时的睡眠都会增加CVDs及死亡风险。

综上,这项研究表明,虽然基因预测有短睡基因,但仍因多睡一会才能降低多种心血管疾病的潜在致病危险因素;而基因预测的长睡基因则不太可能存在上述风险。

 

参考文献:

Ai S, et al. Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank. Eur Heart J. 2021 Apr 5:ehab170. doi: 10.1093/eurheartj/ehab170.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1498864, encodeId=100e1498864dc, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Apr 20 01:11:44 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958306, encodeId=d3e89583068f, content=学习学习 以后注意 再苦再累也要先睡好觉。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:28 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958305, encodeId=51e095830516, content=害、, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:08 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958303, encodeId=23ac95830378, content=每天睡不好,已经是医生的常态了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:01 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958081, encodeId=5de0958081bf, content=每天只有6h睡眠 危⚠️, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fce85481792, createdName=MrDeemo, createdTime=Sun Apr 18 20:45:30 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-19 ZJYYY7

    学习学习 以后注意 再苦再累也要先睡好觉。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1498864, encodeId=100e1498864dc, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Apr 20 01:11:44 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958306, encodeId=d3e89583068f, content=学习学习 以后注意 再苦再累也要先睡好觉。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:28 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958305, encodeId=51e095830516, content=害、, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:08 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958303, encodeId=23ac95830378, content=每天睡不好,已经是医生的常态了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:01 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958081, encodeId=5de0958081bf, content=每天只有6h睡眠 危⚠️, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fce85481792, createdName=MrDeemo, createdTime=Sun Apr 18 20:45:30 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-19 ZJYYY7

    害、

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1498864, encodeId=100e1498864dc, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Apr 20 01:11:44 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958306, encodeId=d3e89583068f, content=学习学习 以后注意 再苦再累也要先睡好觉。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:28 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958305, encodeId=51e095830516, content=害、, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:08 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958303, encodeId=23ac95830378, content=每天睡不好,已经是医生的常态了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:01 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958081, encodeId=5de0958081bf, content=每天只有6h睡眠 危⚠️, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fce85481792, createdName=MrDeemo, createdTime=Sun Apr 18 20:45:30 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-19 ZJYYY7

    每天睡不好,已经是医生的常态了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1498864, encodeId=100e1498864dc, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Apr 20 01:11:44 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958306, encodeId=d3e89583068f, content=学习学习 以后注意 再苦再累也要先睡好觉。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:28 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958305, encodeId=51e095830516, content=害、, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:08 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958303, encodeId=23ac95830378, content=每天睡不好,已经是医生的常态了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ZJYYY7, createdTime=Mon Apr 19 12:15:01 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958081, encodeId=5de0958081bf, content=每天只有6h睡眠 危⚠️, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fce85481792, createdName=MrDeemo, createdTime=Sun Apr 18 20:45:30 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-18 MrDeemo

    每天只有6h睡眠 危⚠️

    0

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