JASN:严重急性呼吸系统综合症或新冠肺炎患者的AKI和主要不良临床结局的风险

2021-01-23 MedSci原创 MedSci原创

SARS患者AKI发生率高于COVID-19患者。AKI与两种疾病患者的主要不良临床结局有关。伴有糖尿病和肝功能异常的患者在SARS和COVID-19感染后出现严重结局的风险增加。

严重急性呼吸系统综合症(SARS)与新冠肺炎COVID-19)密切相关。但AKI对这两种疾病临床结局的影响尚未明确。

近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,这项回顾性全队列研究使用了香港电子公共卫生保健数据库,通过诊断代码,病毒学检查结果或两者相结合来识别SARS或COVID-19患者。该研究的主要终点是入住重症监护病房、有创机械通气的使用和/或死亡的综合结局。

研究人员确定了1670例SARS患者和1040例COVID-19患者(中位年龄分别为41岁和35岁)。在SARS患者中,26%患者达到主要终点,而COVID-19患者为5.3%。糖尿病、肝功能异常和AKI是与SARS或COVID-19患者主要终点显著相关的因素。在SARS患者中,分别有7.9%、2.1%和3.7%发生了1期、2期和3期AKI。在COVID-19的人群中,分别有6.6%、0.4%和1.1%发生了1期、2期和3期AKI。在两组患者中,与AKI显著相关的因素包括糖尿病和高血压。在AKI患者中,与SARS患者相比,COVID-19患者主要不良临床结局发生率较低。肾功能恢复通常在AKI事件发生后30天内出现。

由此可见,SARS患者AKI发生率高于COVID-19患者。AKI与两种疾病患者的主要不良临床结局有关。伴有糖尿病和肝功能异常的患者在SARS和COVID-19感染后出现严重结局的风险增加。

原始出处:

Jeremy Yuen-Chun Teoh,et al.Risks of AKI and Major Adverse Clinical Outcomes in Patients with Severe Acute Respiratory Syndrome or Coronavirus Disease 2019.JASN,2021.https://jasn.asnjournals.org/content/early/2021/01/21/ASN.2020071097

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    2022-01-07 chenhongpeng
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    2021-01-23 ent_xunmeng1987

    学习了

    0

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    2021-01-23 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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