Diabetes Care:合并镰状细胞特性的2型糖尿病患者糖尿病相关并发症的患病率增加

2018-10-17 xing.T MedSci原创

由此可见,SCT可能增加了T2D相关并发症的发生风险,包括视网膜病变、肾病和高血压。

在撒哈拉以南的非洲地区,2型糖尿病(T2D)的患病率正在迅速增加,这些地区镰状细胞特性(SCT)患者也很常见。虽然SCT通常被认为是一种良性疾病,但有证据表明SCT可能会增加T2D的血管功能障碍。然而,目前尚不清楚SCT是否会增加T2D并发症发生的风险。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在确定SCT合并T2D的塞内加尔个体发生T2D并发症是否比仅患有T2D的患者更为普遍。

研究人员比较了SCT合并T2D(T2D-SCT)(n=60)、T2D(n=52)、SCT(n=53)、既无T2D也无SCT(对照)(n=56)个体之间高血压、视网膜病变、周围神经病变、外周动脉疾病和肾功能受损以及动脉硬度、血液流变学和血浆晚期糖基化终产物(AGEs)和细胞因子浓度的发生率。在用肿瘤坏死因子-α和受试者的血浆处理后测量了人主动脉内皮细胞(HAEC)的炎症和粘附因子的表达,研究人员还测量了AGE抑制或泰龙对HAEC中E-选择蛋白表达的影响。

研究人员发现T2D-SCT组个体视网膜病变、高血压和肾功能减退更为普遍,动脉僵硬度、高剪切率血液粘度和触变指数也高于其他组。多变量分析显示血浆AGE浓度与动脉僵硬度显著相关。与其他组相比,用T2D-SCT血浆处理的HAEC中E-选择蛋白表达升高,但AGE抑制逆转了这一改变。

由此可见,SCT可能增加了T2D相关并发症的发生风险,包括视网膜病变、肾病和高血压。

原始出处:

Sarah C. Skinner,et al. Increased Prevalence of Type 2 Diabetes–Related Complications in Combined Type 2 Diabetes and Sickle-Cell Trait.Diabetes Care.2018.https://doi.org/10.2337/dc18-1289

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    2019-05-16 丁鹏鹏
  4. [GetPortalCommentsPageByObjectIdResponse(id=1760808, encodeId=bab21e60808bf, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue May 14 13:01:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800318, encodeId=a41d18003182b, content=<a href='/topic/show?id=dc8be25311a' target=_blank style='color:#2F92EE;'>#相关并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72531, encryptionId=dc8be25311a, topicName=相关并发症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce5632, createdName=jianjun66, createdTime=Sat Jan 12 10:01:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758036, encodeId=85a81e580364c, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Thu May 16 10:01:00 CST 2019, time=2019-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638765, encodeId=722a1638e650e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 11 17:01:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902142, encodeId=017e190214296, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Wed Feb 27 09:01:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351163, encodeId=1ec835116388, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Thu Nov 01 09:34:46 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351060, encodeId=991035106079, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Wed Oct 31 15:09:48 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350935, encodeId=07ea350935fe, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Tue Oct 30 07:57:46 CST 2018, time=2018-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350864, encodeId=4c33350864eb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Mon Oct 29 15:10:30 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350794, encodeId=563d350e948d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Sun Oct 28 21:31:43 CST 2018, time=2018-10-28, status=1, ipAttribution=)]
    2019-03-11 柳叶一刀
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    2018-11-01 月影子说

    学习

    0

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    2018-10-31 月影子说

    学习

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    2018-10-30 月影子说

    学习

    0

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    2018-10-29 月影子说

    学习

    0

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    2018-10-28 月影子说

    学习

    0

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