J Trop Pediatr:小儿急性腹泻怎么办?试试牛初乳

2021-01-14 MedSci原创 MedSci原创

在发展中国家,急性腹泻是导致患儿发病和死亡的一个重大健康问题。目前对儿童急性腹泻的治疗主要集中在输液上,以防止脱水和维持喂养。然而,这并不能改善肠黏膜的愈合,也不能缩短腹泻发作的时间。母乳中含有病原体

在发展中国家,急性腹泻是导致患儿发病和死亡的一个重大健康问题。目前对儿童急性腹泻的治疗主要集中在输液上,以防止脱水和维持喂养。然而,这并不能改善肠黏膜的愈合,也不能缩短腹泻发作的时间。母乳中含有病原体导向的抗体和其他有助于肠道愈合的成分,牛初乳(BC)具有母乳类似的有益作用。但是市售BC在治疗急性胃肠炎、坏死性肠炎及ICU住院患者胃肠道并发症方面的研究很少,其治疗效果尚未确定。近日,发表于J Trop Pediatr的一项随机双盲随机对照试验结果显示,BC不仅可有效治疗急性腹泻患者,还可作为病毒性和细菌性腹泻均的辅助治疗方式。

研究共纳入对160名腹泻患儿,分别接受BC和安慰剂干预。所有病例均调查了导致腹泻的致病菌(沙门氏菌属、志贺氏菌属、腹泻性大肠杆菌(DEC)、弯曲菌属和霍乱弧菌)以及粪便中轮状病毒抗原。

 

结果显示,48小时后,与安慰剂组相比,BC组患儿无论是轮状病毒还是大肠杆菌感染,其呕吐、腹泻和Vesikari评分的频率均显著降低(分别为P = 0.000,P = 0.000,P = 0.000)。

综上所述,该研究结果表明,BC对急性腹泻的治疗效果显著,对病毒性和细菌性腹泻均可考虑作为辅助治疗,以预防腹泻相关并发症。

 

原始出处:

 

Sana Hosny Barakat, Marwa Ahmed Meheissen, et al., Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial. J Trop Pediatr. 2020 Feb 1;66(1):46-55. doi: 10.1093/tropej/fmz029.

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    2021-06-27 feather89
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    2021-01-14 jyzxjiangqin

    好文章!

    0

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