JACC:Brugada综合征诱导的恶性室性心律失常

2018-04-13 MedSci MedSci原创

在指南推荐中,Brugada综合征和由其引起的室性心律失常患者建议安装心律转复除颤器,但是并没有相关的临床证据支持。本研究的目的旨在探究能预测Brugada综合征引起恶性室性心律失常的临床和电生理因素。本研究纳入了88例Brugada综合征患者(组1)和103名无Brugada综合征对照(组2),并对所有研究对象进行了电生理检查和阿马林试验。分析结果显示,在进行阿马林试验前,有53.4%的患者出现

在指南推荐中,Brugada综合征和由其引起的室性心律失常患者建议安装心律转复除颤器,但是并没有相关的临床证据支持。本研究的目的旨在探究能预测Brugada综合征引起恶性室性心律失常的临床和电生理因素。

本研究纳入了88例Brugada综合征患者(组1)和103名无Brugada综合征对照(组2),并对所有研究对象进行了电生理检查和阿马林试验。分析结果显示,在进行阿马林试验前,有53.4%的患者出现了室性心律失常的诱发,组1的患者发生率要更高(65.9% vs 42.7%; p < 0.001),在有室性心律失常的患者中,基底段心室电位持续时间更长(p < 0.001)。在进行阿马林试验后,那些没有诱发心律不齐的患者出现了心律不齐,两组患者间的基底段电位特征无明显差异。基底段电位大小是唯一预测诱发心律不齐的独立预测因子(OR:4.51; 95% Cl: 2.51 - 8.09; p < 0.001)

研究结果显示,在Brugada综合征患者中,动态的基底部电位变化是致命性室性心动过速的病理生理基础,基底段电位大小与室性心律失常独立相关。

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createdTime=Fri Apr 13 11:39:53 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305353, encodeId=827130535330, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Apr 13 09:43:01 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2019-03-13 hbwxf
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    2018-04-16 大爰

    学习了谢谢分享!!

    0

  4. 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createdTime=Fri Apr 13 11:39:53 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305353, encodeId=827130535330, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Apr 13 09:43:01 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-15 般若傻瓜
  5. 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  6. 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  7. 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createdTime=Fri Apr 13 11:39:53 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305353, encodeId=827130535330, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Apr 13 09:43:01 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-15 nymo
  8. 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target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Apr 15 00:35:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590748, encodeId=17e81590e48d1, content=<a href='/topic/show?id=86e23e49d6' target=_blank style='color:#2F92EE;'>#Brugada#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3749, encryptionId=86e23e49d6, topicName=Brugada)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdTime=Fri Apr 13 11:39:53 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305353, encodeId=827130535330, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Apr 13 09:43:01 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 张新亮1853311252142e2fm

    好文章学习了

    0

  9. 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createdBy=939917859602, createdName=nymo, createdTime=Sun Apr 15 00:35:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305397, encodeId=290130539eaa, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Apr 13 12:33:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305379, encodeId=87f43053e9ff, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Apr 13 11:39:53 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305353, encodeId=827130535330, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Apr 13 09:43:01 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  10. 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target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Apr 15 00:35:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590748, encodeId=17e81590e48d1, content=<a href='/topic/show?id=86e23e49d6' target=_blank style='color:#2F92EE;'>#Brugada#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3749, encryptionId=86e23e49d6, topicName=Brugada)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdTime=Fri Apr 13 11:39:53 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305353, encodeId=827130535330, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Apr 13 09:43:01 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 sunfeifeiyang

    0

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