GUT:复发性特发性胃十二指肠溃疡出血的治疗

2019-06-26 MedSci MedSci原创

研究认为,对于幽门螺杆菌阴性的特发性溃疡出血患者,兰索拉唑和法莫替丁对反复出血的预防效果相当

对于幽门螺杆菌阴性的特发性出血溃疡患者,其复发性溃疡并发症风险增加。近日研究人员比较了质子泵抑制剂(兰索拉唑)比组胺2受体拮抗剂 (法莫替丁)对复发性溃疡出血的预防作用。

特发性出血性溃疡病史患者参与研究。在溃疡愈合后,随机接受24个月每天口服兰索拉唑30mg或法莫替丁40mg。主要终点是24个月内复发性上消化道出血。

总计228名患者(每个研究组114名患者)。1例接受兰索拉唑(十二指肠溃疡),3例接受法莫替丁(2例溃疡和1例十二指肠溃疡)患者发生上消化道反复出血。24个月内上消化道出血累计发生率兰索拉唑组为0.88%,法莫替丁组为2.63% (HR:0.33)。无患者使用阿司匹林、非甾体类抗炎药或其他抗血栓药物。

研究认为,对于幽门螺杆菌阴性的特发性溃疡出血患者,兰索拉唑和法莫替丁对反复出血的预防效果相当。

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