PD-1单抗Opdivo联合贝伐单抗和化疗:显着改善非小细胞肺癌患者的无进展生存期

2020-08-04 MedSci原创 MedSci原创

与安慰剂组相比,Opdivo组合组在无进展生存期(PFS)的主要终点方面显示出统计学上的显着改善,并且未发现新的安全问题。

日本小野制药株式会社宣布,PD-1单抗Opdivo(nivolumab)联合抗VEGF(血管内皮生长因子)单抗贝伐单抗Bevacizumab和化疗,治疗非小细胞肺癌的III期临床大获成功。

See the source image

图片来源:http://blog.naver.com/PostView.nhn?blogId=doctorbae75&logNo=221122143614&widgetTypeCall=true

See the source image

图片来源:https://www.slideshare.net/noellecloven/personalized-medicine-66532939

在ONO-4538-52/TASUKI-52研究中,在不适合进行放疗、未经过化疗的IIIB/IV期或复发性非鳞状非小细胞肺癌患者中,将Opdivo组合组(n = 275),与单纯安慰剂联合贝伐单抗和化学疗法(安慰剂组:n = 275)进行比较。

中期分析结果显示:与安慰剂组相比,Opdivo组合组在无进展生存期(PFS)的主要终点方面显示出统计学上的显着改善,并且未发现新的安全问题。

原始出处:

https://www.firstwordpharma.com/node/1746058?tsid=4

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  5. 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  6. 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  7. 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  8. 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  9. 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  10. 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06 11:34:21 CST 2020, time=2020-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806399, encodeId=7c9e806399b6, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Aug 05 22:10:38 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2020-08-05 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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